Rb1 - RB transcriptional corepressor 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24708

Summary

Predicted to enable several functions, including disordered domain specific binding activity; enzyme binding activity; and importin-alpha family protein binding activity. Involved in several processes, including negative regulation of apoptotic process; negative regulation of protein kinase activity; and spermatogenesis. Located in nucleus. Biomarker of acute kidney failure. Human ortholog(s) of this gene implicated in nervous system Cancer (multiple); osteosarcoma; prostate cancer; small cell carcinoma; and urinary bladder Cancer. Orthologous to human RB1 (RB transcriptional corepressor 1). [provided by Alliance of Genome Resources, Apr 2022]

Rb1 Products (1)

mRNA Protein Name
NM_017045.2 NP_058741.2 retinoblastoma-associated protein

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
8945638 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
24027266 RGD
involved in negative regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
24027266 RGD
involved in negative regulation of hepatocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
8649852 RGD
involved in negative regulation of protein serine/threonine kinase activity IMP
IMP: Inferred from mutant phenotype
24027266 RGD
involved in negative regulation of tau-protein kinase activity IMP
IMP: Inferred from mutant phenotype
24027266 RGD
involved in spermatogenesis IEP
IEP: Inferred from expression pattern
15659706 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

retinoblastoma-associated protein

  • Retinoblastoma 1 (including osteosarcoma)

  • pRb

  • pp105

Rb1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Rb1 P33568 Rbbp9 Rattus norvegicus O88350
Anti Bait CoIP
9697699
Intra
Rb1 P33568 E2f1 Rattus norvegicus O09139
Anti Bait CoIP
9697699
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-183118 CID-078 / Phase 1

Pre-clinical Phase

Bioactive Molecules (23)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0039 Ginsenoside Rb1 99.75% Unkown
HY-N0904 Ginsenoside C-K Inhibitor 99.93% Unkown
HY-124962 D-NMAPPD 99.74% Unkown
HY-159805 CDK2-IN-31 Inhibitor 98.22% Unkown
HY-N7678 Gypenoside LXXV 99.79% Unkown
HY-RS11713 RB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N0039R Ginsenoside Rb1 (Standard) 99.26% Unkown
HY-D3376 6-Carboxy-H2DCFDA / Unkown
HY-N0904R Ginsenoside C-K (Standard) Inhibitor / Unkown
HY-N18026 Ginsenoside V / Unkown
HY-N18029 (24S)-Ginsenoside V / Unkown
HY-N18215 Ginsenoside mRb2 / Unkown
HY-N18382 5,6-Didehydroginsenoside Rb1 / Unkown
HY-N18670 Panax notoginseng extract / Unkown
HY-RS06683 IL12RB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11714 RB1CC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11754 RBM45 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174616 Human IL23R mRNA / Unkown
HY-174640 Human IL12RB1 mRNA / Unkown
HY-176853 Myt1-IN-6 Inhibitor / Unkown
HY-N8030 Pseudoginsenoside Rg3 / Unkown
HY-RS16852 Rb1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23293 Rb1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990776 Vimekofusp / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rb1 NCBI NCBI:5925