Slc9a1 - solute carrier family 9 member A1 Gene

Also Known as Nhe1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24782

Summary

Enables sodium:proton antiporter activity. Involved in several processes, including cellular response to electrical stimulus; positive regulation of mitochondrial membrane permeability; and regulation of apoptotic process. Located in several cellular components, including T-tubule; basolateral plasma membrane; and intercalated disc. Used to study cataract; middle cerebral artery infarction; and proteinuria. Biomarker of hyperthyroidism; hypothyroidism; renovascular hypertension; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 19 and congestive heart failure. Orthologous to human SLC9A1 (solute carrier family 9 member A1). [provided by Alliance of Genome Resources, Apr 2022]

Slc9a1 Products (1)

mRNA Protein Name
NM_012652.2 NP_036784.1 sodium/hydrogen exchanger 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12576672 RGD
enables sodium:proton antiporter activity IDA
IDA: Inferred from direct assay
18321853 RGD
enables sodium:proton antiporter activity IMP
IMP: Inferred from mutant phenotype
16002403 RGD
Biological Process GO Annotation Evidence References Source
involved in cardiac muscle cell contraction IEP
IEP: Inferred from expression pattern
20868366 RGD
involved in cell differentiation IEP
IEP: Inferred from expression pattern
16495213 RGD
involved in cellular response to antibiotic IEP
IEP: Inferred from expression pattern
20868366 RGD
involved in cellular response to cold IEP
IEP: Inferred from expression pattern
15452191 RGD
involved in cellular response to electrical stimulus IEP
IEP: Inferred from expression pattern
20868366 RGD
involved in cellular response to hypoxia IDA
IDA: Inferred from direct assay
20868366 RGD
involved in cellular response to insulin stimulus IDA
IDA: Inferred from direct assay
20868366 RGD
involved in cellular response to organic cyclic compound IEP
IEP: Inferred from expression pattern
20868366 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
17552965 RGD
involved in positive regulation of action potential IMP
IMP: Inferred from mutant phenotype
18319243 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
22407349 RGD
involved in positive regulation of cell growth IMP
IMP: Inferred from mutant phenotype
19687166 RGD
involved in positive regulation of intracellular signal transduction IMP
IMP: Inferred from mutant phenotype
14600156 RGD
involved in positive regulation of mitochondrial membrane permeability IMP
IMP: Inferred from mutant phenotype
21297023 RGD
involved in regulation of intracellular pH IMP
IMP: Inferred from mutant phenotype
22387884 RGD
involved in regulation of the force of heart contraction IMP
IMP: Inferred from mutant phenotype
21659487 RGD
involved in response to acidic pH IDA
IDA: Inferred from direct assay
18321853 RGD
involved in response to organic cyclic compound IDA
IDA: Inferred from direct assay
17308111 RGD
Cellular Component GO Annotation Evidence References Source
located in T-tubule IDA
IDA: Inferred from direct assay
20868366 RGD
located in apical plasma membrane IDA
IDA: Inferred from direct assay
23869188 RGD
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
9438178 RGD
located in cell surface IDA
IDA: Inferred from direct assay
20868366 RGD
located in intercalated disc IDA
IDA: Inferred from direct assay
20868366 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
20868366 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
18321853 RGD
located in sarcolemma IDA
IDA: Inferred from direct assay
20868366 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sodium/hydrogen exchanger 1

  • NHE-1

  • Na(+)/H(+) exchanger 1

  • Solute carrier family 9 (sodium/hydrogen exchanger 1), antiporter, Na+/H+, (amiloride sensitive)

  • solute carrier family 9 (sodium/hydrogen exchanger), member 1

  • solute carrier family 9 member 1

  • solute carrier family 9, subf

Slc9a1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Slc9a1 P26431 Chp2 Rattus norvegicus Q810D1
Pull Down
12576672
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13341 SLC9A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13349 SLC9B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19075 Slc9a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25566 Slc9a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc9a1 NCBI NCBI:6548