Cckar - cholecystokinin A receptor Gene

Also Known as Cck-ar

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24889

About Cckar

Primary_assembly 14: 57,292,397-57,300,747 forward strand.mRatBN7.2:CM026987.1

This gene has 1 transcript (splice variant), 202 orthologues, 16 paralogues and is associated with 11 phenotypes. Biased expression in Spleen (RPKM 12.6), Liver (RPKM 3.7) and 4 other tissues.

Summary

Enables Cholecystokinin Receptor activity. Involved in several processes, including positive regulation of somatostatin secretion; reduction of food intake in response to dietary excess; and regulation of metal ion transport. Located in several cellular components, including endosome; lysosome; and terminal bouton. Used to study obesity and type 2 diabetes mellitus. Biomarker of pancreatic Cancer. Human ortholog(s) of this gene implicated in obesity. Orthologous to human CCKAR (cholecystokinin A receptor). [provided by Alliance of Genome Resources, Apr 2022]

Cckar Products (1)

mRNA Protein Name
NM_012688.3 NP_036820.1 cholecystokinin receptor type A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cholecystokinin receptor activity IDA
IDA: Inferred from direct assay
18776046 RGD
Biological Process GO Annotation Evidence References Source
involved in animal organ regeneration IEP
IEP: Inferred from expression pattern
10403848 RGD
involved in cellular response to hormone stimulus IEP
IEP: Inferred from expression pattern
12649564 RGD
involved in eating behavior IMP
IMP: Inferred from mutant phenotype
16728725 RGD
involved in feeding behavior IDA
IDA: Inferred from direct assay
12414437 RGD
involved in gastric acid secretion IDA
IDA: Inferred from direct assay
9773935 RGD
involved in insulin secretion IDA
IDA: Inferred from direct assay
9773935 RGD
involved in pancreas development IEP
IEP: Inferred from expression pattern
10403848 RGD
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
18776046 RGD
involved in positive regulation of somatostatin secretion IMP
IMP: Inferred from mutant phenotype
19959964 RGD
involved in reduction of food intake in response to dietary excess IMP
IMP: Inferred from mutant phenotype
12840200 RGD
involved in regulation of calcium ion transport IDA
IDA: Inferred from direct assay
11207382 RGD
involved in regulation of potassium ion transport IDA
IDA: Inferred from direct assay
12427859 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
7977738 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
17622698 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
15127944 RGD
involved in response to starvation IMP
IMP: Inferred from mutant phenotype
12954406 RGD
involved in response to steroid hormone IEP
IEP: Inferred from expression pattern
16786113 RGD
involved in temperature homeostasis IMP
IMP: Inferred from mutant phenotype
15178543 RGD
Cellular Component GO Annotation Evidence References Source
located in endosome IDA
IDA: Inferred from direct assay
9169450 RGD
located in terminal bouton IDA
IDA: Inferred from direct assay
3408996 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cckar Protein Structure

CholecysA-Rec_N

CholecysA-Rec_N: pfam09193 (15 - 61)

7tm_GPCRs

7tm_GPCRs: cl28897 (56 - 396)

7tm_GPCRs

7tm_GPCRs: cd14964 (58 - 82)

7tm_GPCRs

7tm_GPCRs: cd14964 (91 - 113)

7tm_GPCRs

7tm_GPCRs: cd14964 (129 - 151)

7tm_GPCRs

7tm_GPCRs: cd14964 (174 - 190)

7tm_GPCRs

7tm_GPCRs: cd14964 (221 - 244)

7tm_GPCRs

7tm_GPCRs: cd14964 (327 - 349)

7tm_GPCRs

7tm_GPCRs: cd14964 (364 - 389)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 444 a.a.
Protein Preferred Names Protein Names

cholecystokinin receptor type A

  • CCK-A receptor

  • CCK1-R

  • cholecystokinin-1 receptor

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-128878 Dexloxiglumide Antagonist 98.25% Phase 3
HY-101764 Lintitript Antagonist 99.58% Phase 2
HY-105257 Pranazepide Antagonist 99.81% Phase 2
HY-11077 SR 146131 Agonist 98.23% Phase 1

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1096 A71623 Agonist 99.34% Unkown
HY-B2154 Loxiglumide Antagonist 98.0% Unkown
HY-129810 PD 135158 Antagonist / Unkown
HY-U00363 CHEMBL333994 Antagonist / Unkown
HY-123434 PD-149164 Agonist / Unkown
HY-119127 TP-680 Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cckar NCBI NCBI:886