GNMT - Gnmt glycine N-methyltransferase Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 25134

Summary

Enables several functions, including S-adenosyl-L-methionine binding activity; carboxylic acid binding activity; and glycine N-methyltransferase activity. Involved in several processes, including S-adenosylmethionine metabolic process; alpha-amino acid metabolic process; and protein homotetramerization. Located in cytosol and nucleus. Part of methyltransferase complex. Human ortholog(s) of this gene implicated in glycine N-methyltransferase deficiency. Orthologous to human GNMT (glycine N-methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

GNMT Products (1)

mRNA	Protein	Name
NM_017084.1	NP_058780.1	glycine N-methyltransferase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables S-adenosyl-L-methionine binding	IMP IMP: Inferred from mutant phenotype	10756111	RGD
enables S-adenosylmethionine-dependent methyltransferase activity	IDA IDA: Inferred from direct assay	15347642	RGD
enables folic acid binding	IDA IDA: Inferred from direct assay	17158459	RGD
enables glycine N-methyltransferase activity	IDA IDA: Inferred from direct assay	12054489	RGD
enables glycine N-methyltransferase activity	IMP IMP: Inferred from mutant phenotype	10756111	RGD
enables glycine binding	IDA IDA: Inferred from direct assay	15340920	RGD
enables glycine binding	IMP IMP: Inferred from mutant phenotype	10756111	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	10756111	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in S-adenosylhomocysteine metabolic process	IDA IDA: Inferred from direct assay	15347642	RGD
involved in S-adenosylhomocysteine metabolic process	IMP IMP: Inferred from mutant phenotype	10756111	RGD
involved in S-adenosylmethionine metabolic process	IDA IDA: Inferred from direct assay	15340920	RGD
involved in S-adenosylmethionine metabolic process	IMP IMP: Inferred from mutant phenotype	10756111	RGD
involved in glycine metabolic process	IMP IMP: Inferred from mutant phenotype	10756111	RGD
involved in methylation	IMP IMP: Inferred from mutant phenotype	10756111	RGD
involved in protein homotetramerization	IPI IPI: Inferred from physical interaction	15340920	RGD
involved in sarcosine metabolic process	IMP IMP: Inferred from mutant phenotype	18501206	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	6587377	RGD
part of methyltransferase complex	IMP IMP: Inferred from mutant phenotype	10756111	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
glycine N-methyltransferase	folate-binding protein glycine methyltransferase

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05569	GNMT Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17639	Gnmt Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24099	Gnmt Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	GNMT	NCBI	NCBI:27232