Pgr - progesterone receptor Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25154

About Pgr

Primary_assembly 8: 6,072,673-6,131,344 forward strand.mRatBN7.2:CM026981.1

This gene has 1 transcript (splice variant), 193 orthologues, 8 paralogues and is associated with 19 phenotypes. Biased expression in Uterus (RPKM 178.1), Brain (RPKM 36.9) and 1 other tissue.

Summary

Enables several functions, including sequence-specific DNA binding activity; steroid binding activity; and steroid hormone receptor activity. Involved in several processes, including cellular response to gonadotropin stimulus; estrous cycle; and regulation of transcription, DNA-templated. Located in several cellular components, including axon terminus; dendritic spine; and perikaryon. Biomarker of endometriosis and polycystic ovary syndrome. Human ortholog(s) of this gene implicated in endometriosis; hyperprolactinemia; and obesity. Orthologous to human PGR (Progesterone Receptor). [provided by Alliance of Genome Resources, Apr 2022]

Pgr Products (1)

mRNA Protein Name
NM_022847.2 NP_074038.2 progesterone receptor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables hormone binding IMP
IMP: Inferred from mutant phenotype
11113338 RGD
enables nuclear steroid receptor activity IMP
IMP: Inferred from mutant phenotype
11113338 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16020483 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
17109827 RGD
enables steroid binding IMP
IMP: Inferred from mutant phenotype
11113338 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to estrogen stimulus IEP
IEP: Inferred from expression pattern
17272396 RGD
involved in cellular response to follicle-stimulating hormone stimulus IEP
IEP: Inferred from expression pattern
8344215 RGD
involved in cellular response to gonadotropin stimulus IEP
IEP: Inferred from expression pattern
8344215 RGD
involved in cellular response to luteinizing hormone stimulus IEP
IEP: Inferred from expression pattern
8344215 RGD
involved in cellular response to wortmannin IEP
IEP: Inferred from expression pattern
17272396 RGD
involved in diterpenoid metabolic process IEP
IEP: Inferred from expression pattern
8344215 RGD
involved in estrous cycle IEP
IEP: Inferred from expression pattern
16461543 RGD
involved in female mating behavior IMP
IMP: Inferred from mutant phenotype
19094083 RGD
involved in luteinization IEP
IEP: Inferred from expression pattern
8344215 RGD
involved in negative regulation of DNA-templated transcription IEP
IEP: Inferred from expression pattern
12457039 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
22778216 RGD
involved in negative regulation of granulosa cell apoptotic process IMP
IMP: Inferred from mutant phenotype
19208546 RGD
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
8344215 RGD
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
16020483 RGD
involved in positive regulation of smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
21440892 RGD
involved in response to cocaine IDA
IDA: Inferred from direct assay
17109827 RGD
involved in response to estrogen IEP
IEP: Inferred from expression pattern
22147012 RGD
involved in response to progesterone IEP
IEP: Inferred from expression pattern
22147012 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
18720413 RGD
located in axon terminus IDA
IDA: Inferred from direct assay
18720413 RGD
located in dendrite IDA
IDA: Inferred from direct assay
18720413 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
18720413 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
18720413 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pgr Protein Structure

Prog_receptor

Prog_receptor: pfam02161 (0 - 556)

NR_DBD_GR_PR

NR_DBD_GR_PR: cd07172 (555 - 632)

NR_LBD_PR

NR_LBD_PR: cd07074 (678 - 925)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 926 a.a.
Protein Preferred Names Protein Names

progesterone receptor

  • PR

  • nuclear receptor subfamily 3 group C member 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10396 PGR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10397 Pgr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10398 Pgr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-164997 15-keto Prostaglandin F1α / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pgr NCBI NCBI:5241