Dgat2 - diacylglycerol O-acyltransferase 2 Gene

Also Known as ARAT

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 252900

Summary

Enables diacylglycerol O-acyltransferase activity. Involved in several processes, including bile acid signaling pathway; positive regulation of gluconeogenesis; and regulation of lipid metabolic process. Located in intracellular membrane-bounded organelle. Used to study fatty liver disease. Biomarker of chronic kidney disease; non-alcoholic fatty liver disease; and premature menopause. Human ortholog(s) of this gene implicated in non-alcoholic fatty liver disease. Orthologous to human DGAT2 (diacylglycerol O-acyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]

Dgat2 Products (1)

mRNA Protein Name
NM_001012345.1 NP_001012345.1 diacylglycerol O-acyltransferase 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables diacylglycerol O-acyltransferase activity IDA
IDA: Inferred from direct assay
12235188 RGD
Biological Process GO Annotation Evidence References Source
involved in diacylglycerol metabolic process IMP
IMP: Inferred from mutant phenotype
17526931 RGD
involved in negative regulation of fatty acid oxidation IMP
IMP: Inferred from mutant phenotype
17526931 RGD
involved in positive regulation of gluconeogenesis IMP
IMP: Inferred from mutant phenotype
17526931 RGD
involved in positive regulation of triglyceride biosynthetic process IMP
IMP: Inferred from mutant phenotype
17526931 RGD
involved in regulation of cholesterol metabolic process IMP
IMP: Inferred from mutant phenotype
17526931 RGD
involved in regulation of lipoprotein metabolic process IMP
IMP: Inferred from mutant phenotype
17526931 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
26394137 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

diacylglycerol O-acyltransferase 2

  • acyl-CoA retinol O-fatty-acyltransferase

  • diglyceride acyltransferase 2

  • retinol O-fatty-acyltransferase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-153507 DGAT1-IN-4 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dgat2 NCBI NCBI:84649