Casp3 - caspase 3 Gene

Also Known as Lice; Yama; CPP32-beta

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25402

About Casp3

Primary_assembly 16: 45,662,910-45,684,648 reverse strand.mRatBN7.2:CM026989.1

This gene has 1 transcript (splice variant), 334 orthologues, 12 paralogues and is associated with 107 phenotypes. Biased expression in Thymus (RPKM 222.5), Spleen (RPKM 187.9) and 9 other tissues.

Summary

Enables several functions, including death receptor binding activity; Phospholipase A2 activator activity; and protease binding activity. Involved in several processes, including luteolysis; nervous system development; and positive regulation of amyloid-beta formation. Located in cytosol; membrane raft; and neuronal cell body. Part of death-inducing signaling complex. Used to study artery disease (multiple); brain disease (multiple); and pre-malignant neoplasm. Biomarker of several diseases, including artery disease (multiple); brain disease (multiple); diabetes mellitus (multiple); heart disease (multiple); and pancreatitis (multiple). Human ortholog(s) of this gene implicated in Parkinson's disease; colon cancer; lung non-small cell carcinoma; and stomach Cancer. Orthologous to human CASP3 (Caspase 3). [provided by Alliance of Genome Resources, Apr 2022]

Casp3 Products (1)

mRNA Protein Name
NM_012922.2 NP_037054.1 caspase-3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cysteine-type peptidase activity IDA
IDA: Inferred from direct assay
16336964 RGD
enables death receptor binding IPI
IPI: Inferred from physical interaction
17518537 RGD
enables phospholipase A2 activator activity IMP
IMP: Inferred from mutant phenotype
12492473 RGD
enables protease binding IPI
IPI: Inferred from physical interaction
17518537 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
18485100 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
17518537 RGD
Biological Process GO Annotation Evidence References Source
involved in axonal fasciculation IMP
IMP: Inferred from mutant phenotype
25898930 RGD
involved in cellular response to organic cyclic compound IEP
IEP: Inferred from expression pattern
16987298 RGD
involved in glial cell apoptotic process IEP
IEP: Inferred from expression pattern
18931364 RGD
involved in hippocampus development IEP
IEP: Inferred from expression pattern
18459132 RGD
involved in intracellular signal transduction IMP
IMP: Inferred from mutant phenotype
12492473 RGD
involved in learning or memory IMP
IMP: Inferred from mutant phenotype
18239768 RGD
involved in leukocyte apoptotic process IEP
IEP: Inferred from expression pattern
26861981 RGD
involved in luteolysis IEP
IEP: Inferred from expression pattern
25332219 RGD
involved in neuron differentiation IEP
IEP: Inferred from expression pattern
15248196 RGD
involved in positive regulation of amyloid-beta formation IDA
IDA: Inferred from direct assay
17553422 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
17869439 RGD
involved in positive regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
18404518 RGD
involved in protein catabolic process IDA
IDA: Inferred from direct assay
15004018 RGD
involved in proteolysis IDA
IDA: Inferred from direct assay
17553422 RGD
involved in regulation of protein stability IDA
IDA: Inferred from direct assay
17553422 RGD
involved in response to X-ray IEP
IEP: Inferred from expression pattern
18239382 RGD
involved in response to amino acid IEP
IEP: Inferred from expression pattern
18423997 RGD
involved in response to cobalt ion IEP
IEP: Inferred from expression pattern
18598848 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
18598848 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
18288275 RGD
involved in response to glucose IDA
IDA: Inferred from direct assay
19356108 RGD
involved in response to hydrogen peroxide IDA
IDA: Inferred from direct assay
18479463 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
18466900 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
18289516 RGD
involved in response to metal ion IEP
IEP: Inferred from expression pattern
18483861 RGD
involved in response to nicotine IEP
IEP: Inferred from expression pattern
18477628 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
18255115 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
18274634 RGD
involved in striated muscle cell differentiation IEP
IEP: Inferred from expression pattern
28899909 RGD
Cellular Component GO Annotation Evidence References Source
part of death-inducing signaling complex IDA
IDA: Inferred from direct assay
17518537 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
25898930 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Casp3 Protein Structure

CASc

CASc: smart00115 (36 - 276)

  • 0
  • 100
  • 200
  • 277 a.a.
Protein Preferred Names Protein Names

caspase-3

  • CASP-3

  • CPP-32

  • CPP32beta

  • Caspase 3, apoptosis related cysteine protease (ICE-like cysteine protease)

  • IRP

  • SCA-1

  • SREBP cleavage activity 1

  • apopain

  • cysteine protease CPP32

  • cysteine protease p32-beta

  • protein Yama

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N10336 Notoginsenoside R4 99.90% Unkown
HY-RS01952 CASP3 Human Pre-designed siRNA Set A / Unkown
HY-10132 CASP3 activator 1 Activator / Unkown
HY-175177 XIAP-CASP7 PPI-IN-1 / Unkown
HY-177208 BW-AQ-113 / Unkown
HY-P10656 Ac-DEVDD-TPP Inducer / Unkown
HY-RS01953 Casp3 Mouse Pre-designed siRNA Set A / Unkown
HY-RS01954 Casp3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Casp3 NCBI NCBI:836