Cd44 - CD44 molecule (Indian blood group) Gene

Also Known as CD44A; METAA; RHAMM

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25406

Summary

Enables epidermal growth factor receptor binding activity; phosphoprotein binding activity; and protein kinase binding activity. Involved in several processes, including blood vessel maturation; macrophage fusion; and positive regulation of neutrophil apoptotic process. Located in apical plasma membrane; basolateral plasma membrane; and nucleus. Part of protein-containing complex. Biomarker of borna disease and cholestasis. Human ortholog(s) of this gene implicated in breast carcinoma (multiple); carcinoma (multiple); and prostate Cancer. Orthologous to human CD44 (CD44 molecule (Indian blood group)). [provided by Alliance of Genome Resources, Apr 2022]

Cd44 Products (1)

mRNA Protein Name
NM_012924.3 NP_037056.3 CD44 antigen precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables epidermal growth factor receptor binding IPI
IPI: Inferred from physical interaction
21349584 RGD
enables phosphoprotein binding IPI
IPI: Inferred from physical interaction
11316791 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15659388 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
8103744 RGD
Biological Process GO Annotation Evidence References Source
involved in blood vessel maturation IEP
IEP: Inferred from expression pattern
15947460 RGD
involved in cell adhesion IMP
IMP: Inferred from mutant phenotype
16306150 RGD
involved in cell migration IMP
IMP: Inferred from mutant phenotype
16306150 RGD
involved in macrophage fusion IMP
IMP: Inferred from mutant phenotype
16195325 RGD
involved in neuron projection development IMP
IMP: Inferred from mutant phenotype
17760872 RGD
involved in positive regulation of neutrophil apoptotic process IMP
IMP: Inferred from mutant phenotype
11044212 RGD
involved in postsynapse organization IDA
IDA: Inferred from direct assay
27798233 RGD
involved in postsynapse organization IMP
IMP: Inferred from mutant phenotype
27798233 RGD
involved in regulation of cell growth IDA
IDA: Inferred from direct assay
11316791 RGD
involved in regulation of modification of postsynaptic structure EXP
EXP: Inferred from Experiment
27798233 RGD
involved in regulation of modification of postsynaptic structure IDA
IDA: Inferred from direct assay
27798233 RGD
involved in regulation of modification of postsynaptic structure IMP
IMP: Inferred from mutant phenotype
27798233 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
31966914 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
17105903 RGD
involved in response to vitamin A IEP
IEP: Inferred from expression pattern
16804311 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
16786159 RGD
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
16786159 RGD
located in cell surface IDA
IDA: Inferred from direct assay
31723344 RGD
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
27798233 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
27798233 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
27798233 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
27798233 RGD
is active in presynapse IDA
IDA: Inferred from direct assay
27798233 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
11316791 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

CD44 antigen

  • Cell surface glycoprotein CD44 (hyaluronate binding protein)

  • ECMR-III

  • GP90 lymphocyte homing/adhesion receptor

  • HUTCH-I

  • PGP-1

  • PGP-I

  • extracellular matrix receptor III

  • hermes antigen

  • hyaluronate receptor

  • phagocytic glycoprotein 1

  • phagocytic glycopr

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-154812 Gintemetostat Inhibitor 99.81% Unkown
HY-149897 HA-CD44 interaction inhibitor 2 Inhibitor 99.36% Unkown
HY-149898 HA-CD44 interaction inhibitor 1 Inhibitor 99.34% Unkown
HY-B0633D Hyaluronic acid sodium (MW 200-1560) Ligand 99.41% Unkown
HY-B0633E Hyaluronic acid, low endotoxin Ligand / Unkown
HY-P5352 Hyaluronan-IN-1 Inhibitor 99.84% Unkown
HY-W015860 3-Methylbenzene-1,2-diamine Ligand / Unkown
HY-181781 LSD1-IN-48 Inhibitor / Unkown
HY-E70182 Hyaluronidase 2 Inhibitor / Unkown
HY-175809 SRT6 Inhibitor / Unkown
Inhibitory Antibodies (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99126 Anti-Mouse/Human CD44 Antibody (IM7) Inhibitor 99.07% Unkown
HY-P992437 PF-03475952 Inhibitor / Unkown
HY-P991756 Anti-Mouse CD44 Antibody (KM703) Inhibitor / Unkown
HY-P991559 Anti-CD44 Antibody Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cd44 NCBI NCBI:960