Smad3 - SMAD family member 3 Gene

Also Known as mad3; Madh3; Smad 3

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25631

Summary

Enables several functions, including DNA-binding transcription factor activity; SMAD binding activity; and beta-catenin binding activity. Involved in several processes, including positive regulation of hydrolase activity; regulation of gene expression; and transmembrane receptor protein serine/threonine kinase signaling pathway. Located in cytoplasm and nucleus. Part of transcription regulator complex. Used to study pre-malignant neoplasm. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 3; Lynch syndrome; and pancreatic Cancer. Orthologous to human SMAD3 (Smad Family member 3). [provided by Alliance of Genome Resources, Apr 2022]

Smad3 Products (1)

mRNA Protein Name
NM_013095.3 NP_037227.1 mothers against decapentaplegic homolog 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
12702545 RGD
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
22073128 RGD
enables beta-catenin binding IDA
IDA: Inferred from direct assay
20097766 RGD
enables enzyme binding IPI
IPI: Inferred from physical interaction
22073128 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16362038 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
12702545 RGD
Biological Process GO Annotation Evidence References Source
involved in SMAD protein signal transduction IMP
IMP: Inferred from mutant phenotype
22073128 RGD
involved in activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
11839804 RGD
involved in adrenal gland development IDA
IDA: Inferred from direct assay
12844345 RGD
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
32065356 RGD
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: Inferred from expression pattern
33409963 RGD
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
14517210 RGD
involved in negative regulation of cardiac muscle hypertrophy in response to stress IGI
IGI: Inferred from genetic interaction
27038547 RGD
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
15987742 RGD
involved in negative regulation of lung blood pressure IGI
IGI: Inferred from genetic interaction
27038547 RGD
involved in negative regulation of protein catabolic process IDA
IDA: Inferred from direct assay
16690606 RGD
involved in negative regulation of protein catabolic process IMP
IMP: Inferred from mutant phenotype
20097766 RGD
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
16205635 RGD
involved in positive regulation of alkaline phosphatase activity IDA
IDA: Inferred from direct assay
12096832 RGD
involved in positive regulation of bone mineralization IDA
IDA: Inferred from direct assay
12096832 RGD
involved in positive regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
20097766 RGD
involved in positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
17545585 RGD
involved in positive regulation of focal adhesion assembly IDA
IDA: Inferred from direct assay
15987742 RGD
involved in positive regulation of interleukin-1 beta production IMP
IMP: Inferred from mutant phenotype
16371439 RGD
involved in positive regulation of nitric oxide biosynthetic process IGI
IGI: Inferred from genetic interaction
27038547 RGD
involved in positive regulation of positive chemotaxis IDA
IDA: Inferred from direct assay
15987742 RGD
involved in positive regulation of stress fiber assembly IDA
IDA: Inferred from direct assay
15987742 RGD
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12702545 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
16891311 RGD
involved in positive regulation of transforming growth factor beta3 production IMP
IMP: Inferred from mutant phenotype
16891311 RGD
involved in protein stabilization IMP
IMP: Inferred from mutant phenotype
20097766 RGD
involved in signal transduction involved in regulation of gene expression IMP
IMP: Inferred from mutant phenotype
22073128 RGD
involved in transdifferentiation IDA
IDA: Inferred from direct assay
15987742 RGD
involved in transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
16371439 RGD
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
16690606 RGD
part of transcription regulator complex IDA
IDA: Inferred from direct assay
16891311 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mothers against decapentaplegic homolog 3

  • MAD (mothers against decapentaplegic, Drosophila) homolog 3

  • MAD homolog 3

  • mothers against DPP homolog 3

Smad3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Smad3 P84025 Akt1 Rattus norvegicus P47196
Anti Tag CoIP
16362038
Intra
Smad3 P84025 Akt1 Rattus norvegicus P47196
Anti Bait CoIP
16362038
Cross
Smad3 P84025 N Human SARS coronavirus P59595
Pull Down
18055455
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-147025 (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine Inhibitor 98.62% Unkown
HY-187219 CX-Se13 Inhibitor / Unkown
HY-P11914 Peptide CYP9 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Smad3 NCBI NCBI:4088