2. Gene
  3. Akt1 - AKT serine/threonine kinase 1 Gene

Akt1 - AKT serine/threonine kinase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Akt

Gene ID: 24185 | Gene type: protein coding

About Akt1

Primary_assembly 6: 131,713,720-131,733,921 reverse strand.mRatBN7.2:CM026979.1

This gene has 5 transcripts (splice variants), 219 orthologues, 5 paralogues and is associated with 108 phenotypes. Biased expression in Heart (RPKM 317.3), Adrenal (RPKM 243.5) and 9 other tissues.

Summary

Enables several functions, including ATP binding activity; GTPase activating protein binding activity; and Enzyme binding activity. Involved in several processes, including cellular macromolecule biosynthetic process; cellular response to mechanical stimulus; and regulation of cellular protein metabolic process. Acts upstream of or within several processes, including cellular response to Insulin stimulus; negative regulation of cell size; and positive regulation of sodium ion transport. Located in cytosol; mitochondrion; and nucleus. Used to study autosomal recessive polycystic kidney disease; hypertension; impotence; myocardial infarction; and type 2 diabetes mellitus. Biomarker of several diseases, including brain ischemia; colon cancer; diabetic retinopathy; type 2 diabetes mellitus; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including Cowden syndrome 6; breast Cancer (multiple); lung disease (multiple); pancreatic Cancer (multiple); and reproductive organ Cancer (multiple). Orthologous to human Akt1 (Akt serine/threonine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Akt1 Products(2)

mRNA Protein Name
NM_033230.3 NP_150233.1 RAC-alpha serine/threonine-protein kinase
NM_033230.3 NP_150233.1 RAC-alpha serine/threonine-protein kinase

Akt1 Protein Structure

PH_PKB

PH_PKB: cd01241 (3 - 110)

STKc_PKB_alpha

STKc_PKB_alpha: cd05594 (123 - 478)

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  • 480 a.a.
Protein Preferred Names Protein Names

RAC-alpha serine/threonine-protein kinase

AKT1 kinase

PKB alpha

RAC protein kinase alpha RAC-PK alpha

RAC-PK-alpha

murine thymoma viral (v-akt) oncogene homolog 1

protein kinase B alpha

thymoma viral proto-oncogene 1

v-akt murine thymoma viral oncogene homolog 1

Related Agents

Clinical Phase
Bioactive Molecules (19)
Cat. No. Product Name Effect
Purity Phase
HY-15186 Ipatasertib 99.88% Phase 4
HY-N0004 Oridonin Inhibitor 99.89% Phase 4
HY-15186A Ipatasertib dihydrochloride Inhibitor 99.27% Phase 4
HY-15431 Capivasertib Inhibitor 99.95% Phase 3
HY-10358 MK-2206 dihydrochloride 99.99% Phase 2
HY-19719 Miransertib Inhibitor 99.32% Phase 2
HY-15727 Afuresertib Inhibitor 99.54% Phase 2
HY-15965 Uprosertib Inhibitor 99.74% Phase 2
HY-19934A Pifusertib hydrochloride 98.96% Phase 2
HY-15727A Afuresertib hydrochloride Inhibitor 99.03% Phase 2
HY-19719A Miransertib hydrochloride Inhibitor 99.74% Phase 2
HY-19934 Pifusertib / Phase 2
HY-108232 MK-2206 / Phase 2
HY-15965A Uprosertib hydrochloride Inhibitor / Phase 2
HY-10249 GSK-690693 98.46% Phase 1
HY-100018 BAY1125976 Inhibitor 99.74% Phase 1
HY-16071 AT13148 Inhibitor 99.21% Phase 1
HY-100501 M2698 99.87% Phase 1
HY-137458 Vevorisertib Inhibitor / Phase 1
Pre-clinical Phase
Bioactive Molecules (60)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-18749 SC79 Activator ≥98.0% Unkown
HY-10355 AKT inhibitor VIII 98.97% Unkown
HY-107738 Guggulsterone 99.95% Unkown
HY-10425 A-443654 Inhibitor 98.50% Unkown
HY-13254 A-674563 Inhibitor 99.87% Unkown
HY-N1435 Oroxin B 99.71% Unkown
HY-11005 BX-912 99.13% Unkown
HY-137458A Vevorisertib trihydrochloride Inhibitor 99.13% Unkown
HY-12059 AT7867 Inhibitor 99.88% Unkown
HY-133120 INY-03-041 Inhibitor 98.64% Unkown
HY-18271 CaMKII-IN-1 Inhibitor 98.02% Unkown
HY-13254A A-674563 hydrochloride Inhibitor 99.86% Unkown
HY-151504 ALM301 Inhibitor 99.33% Unkown
HY-12059A AT7867 dihydrochloride Inhibitor 99.75% Unkown
HY-145282 MS170 Inhibitor 99.72% Unkown
HY-16666 3CAI Inhibitor 99.97% Unkown
HY-151613A MS15 TFA Degrader 99.86% Unkown
HY-19982 AKT-IN-6 99.51% Unkown
HY-50862 Akt1/Akt2-IN-1 Inhibitor 99.59% Unkown
HY-119016 SK1-I Inhibitor 98.47% Unkown
HY-160093 SQLE-IN-1 98.82% Unkown
HY-134903 (32-Carbonyl)-RMC-5552 Inhibitor 95.04% Unkown
HY-119016A SK1-​I hydrochloride Inhibitor 99.49% Unkown
HY-126257 AKT-IN-3 Inhibitor 99.29% Unkown
HY-151613 MS15 Inhibitor / Unkown
HY-133120A INY-03-041 trihydrochloride Inhibitor 99.27% Unkown
HY-123390 DB07107 Inhibitor / Unkown
HY-146459 Akt1-IN-1 Inhibitor 99.74% Unkown
HY-148868 Akt1&PKA-IN-1 Inhibitor / Unkown
HY-148868A Akt1&PKA-IN-2 Inhibitor / Unkown
HY-N8122 24-Methylenecycloartanyl ferulate Inhibitor 98.05% Unkown
HY-130985 9-Decyn-1-ol / Unkown
HY-145281 MS98 Inhibitor / Unkown
HY-10357 MK-2206 free base / Unkown
HY-112148 AKT-IN-2 Inhibitor / Unkown
HY-132302 Hu7691 Inhibitor / Unkown
HY-132302A Hu7691 free base Inhibitor / Unkown
HY-147935 NTQ1062 Inhibitor / Unkown
HY-107586 Demethylasterriquinone B1 Activator / Unkown
HY-129119 Akt1/Akt2-IN-2 / Unkown
HY-138767 AKT-IN-5 Inhibitor / Unkown
HY-143611 AKT-IN-8 Inhibitor / Unkown
HY-145244 APN/AKT-IN-1 Inhibitor / Unkown
HY-147937 AKT-IN-13 Inhibitor / Unkown
HY-153640 AKT-IN-14 Inhibitor / Unkown
HY-153640A AKT-IN-14 free base Inhibitor / Unkown
HY-154960 Tubulin/AKT1-IN-1 / Unkown
HY-161321 PTP1B-IN-24 / Unkown
HY-161438 Akt1-IN-3 Inhibitor / Unkown
HY-161439 Akt1-IN-4 Inhibitor / Unkown
HY-162285 Anticancer agent 189 Inhibitor / Unkown
HY-RS00542 AKT1 Human Pre-designed siRNA Set A / Unkown
HY-RS00543 Akt1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS00544 Akt1 Rat Pre-designed siRNA Set A / Unkown
HY-RS00545 AKT1S1 Human Pre-designed siRNA Set A / Unkown
HY-W013816 Dipentyl phthalate 99.42% Unkown
HY-W750451 Reptoside / Unkown
HY-16032 Akt1-IN-2 Inhibitor / Unkown
HY-162102 DDR1-IN-8 Inhibitor / Unkown
HY-P5910 Azurin p28 peptide Inducer / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Akt1 NCBI NCBI:207