Akt1 - AKT serine/threonine kinase 1 Gene

Also Known as Akt

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24185

About Akt1

Primary_assembly 6: 131,713,720-131,733,921 reverse strand.mRatBN7.2:CM026979.1

This gene has 5 transcripts (splice variants), 219 orthologues, 5 paralogues and is associated with 108 phenotypes. Biased expression in Heart (RPKM 317.3), Adrenal (RPKM 243.5) and 9 other tissues.

Summary

Enables several functions, including ATP binding activity; GTPase activating protein binding activity; and enzyme binding activity. Involved in several processes, including cellular macromolecule biosynthetic process; cellular response to mechanical stimulus; and regulation of cellular protein metabolic process. Acts upstream of or within several processes, including cellular response to Insulin stimulus; negative regulation of cell size; and positive regulation of sodium ion transport. Located in cytosol; mitochondrion; and nucleus. Used to study autosomal recessive polycystic kidney disease; hypertension; impotence; myocardial infarction; and type 2 diabetes mellitus. Biomarker of several diseases, including brain ischemia; colon cancer; diabetic retinopathy; type 2 diabetes mellitus; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including Cowden syndrome 6; breast Cancer (multiple); lung disease (multiple); pancreatic Cancer (multiple); and reproductive organ Cancer (multiple). Orthologous to human Akt1 (Akt serine/threonine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Akt1 Products (2)

mRNA Protein Name
NM_033230.3 NP_150233.1 RAC-alpha serine/threonine-protein kinase
NM_033230.3 NP_150233.1 RAC-alpha serine/threonine-protein kinase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
9887206 RGD
enables GTPase activating protein binding IPI
IPI: Inferred from physical interaction
14707121 RGD
enables enzyme binding IPI
IPI: Inferred from physical interaction
10454575 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12194869 RGD
enables protein kinase C binding IPI
IPI: Inferred from physical interaction
7488143 RGD
enables protein kinase activity IDA
IDA: Inferred from direct assay
12084817 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
24583056 RGD
enables protein phosphatase 2A binding IPI
IPI: Inferred from physical interaction
11884620 RGD
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
8524413 RGD
enables protein serine/threonine kinase binding IPI
IPI: Inferred from physical interaction
8524413 RGD
enables protein serine/threonine kinase inhibitor activity IPI
IPI: Inferred from physical interaction
8524413 RGD
Biological Process GO Annotation Evidence References Source
involved in DNA damage response IDA
IDA: Inferred from direct assay
20605787 RGD
acts upstream of or within cell projection organization IDA
IDA: Inferred from direct assay
16286931 RGD
involved in cellular response to hypoxia IDA
IDA: Inferred from direct assay
20515660 RGD
involved in cellular response to insulin stimulus IDA
IDA: Inferred from direct assay
9065430 RGD
acts upstream of or within cellular response to insulin stimulus IMP
IMP: Inferred from mutant phenotype
17715136 RGD
involved in cellular response to insulin stimulus IMP
IMP: Inferred from mutant phenotype
10454575 RGD
involved in cellular response to mechanical stimulus IDA
IDA: Inferred from direct assay
20042609 RGD
involved in cellular response to nerve growth factor stimulus IDA
IDA: Inferred from direct assay
20605787 RGD
involved in cellular response to nerve growth factor stimulus IEP
IEP: Inferred from expression pattern
9492284 RGD
involved in cellular response to organic cyclic compound IDA
IDA: Inferred from direct assay
11812651 RGD
involved in glycogen biosynthetic process IMP
IMP: Inferred from mutant phenotype
10400692 RGD
involved in insulin receptor signaling pathway IDA
IDA: Inferred from direct assay
8524413 RGD
involved in insulin receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
9632753 RGD
involved in negative regulation of JNK cascade IDA
IDA: Inferred from direct assay
17064355 RGD
involved in negative regulation of calcium import into the mitochondrion IMP
IMP: Inferred from mutant phenotype
24601882 RGD
acts upstream of or within negative regulation of cell size IDA
IDA: Inferred from direct assay
16286931 RGD
involved in negative regulation of protein kinase activity IDA
IDA: Inferred from direct assay
8524413 RGD
involved in negative regulation of superoxide anion generation IMP
IMP: Inferred from mutant phenotype
24601882 RGD
involved in peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
8524413 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
20403980 RGD
involved in positive regulation of cell growth IDA
IDA: Inferred from direct assay
12084817 RGD
involved in positive regulation of mitochondrial membrane potential IMP
IMP: Inferred from mutant phenotype
24601882 RGD
involved in positive regulation of protein metabolic process IMP
IMP: Inferred from mutant phenotype
9632753 RGD
acts upstream of or within positive regulation of sodium ion transport IMP
IMP: Inferred from mutant phenotype
17715136 RGD
involved in positive regulation of vasoconstriction IMP
IMP: Inferred from mutant phenotype
21532183 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
9887206 RGD
involved in regulation of aerobic respiration IMP
IMP: Inferred from mutant phenotype
24601882 RGD
involved in regulation of cell migration IMP
IMP: Inferred from mutant phenotype
17109063 RGD
acts upstream of or within regulation of protein localization IMP
IMP: Inferred from mutant phenotype
17715136 RGD
involved in response to ischemia IEP
IEP: Inferred from expression pattern
24601882 RGD
involved in spinal cord development IDA
IDA: Inferred from direct assay
23681769 RGD
involved in translation IMP
IMP: Inferred from mutant phenotype
9632753 RGD
Cellular Component GO Annotation Evidence References Source
located in dendrite IDA
IDA: Inferred from direct assay
31071414 RGD
located in nucleus IDA
IDA: Inferred from direct assay
20605787 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Akt1 Protein Structure

PH_PKB

PH_PKB: cd01241 (3 - 110)

STKc_PKB_alpha

STKc_PKB_alpha: cd05594 (123 - 478)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 480 a.a.
Protein Preferred Names Protein Names

RAC-alpha serine/threonine-protein kinase

  • AKT1 kinase

  • PKB alpha

  • RAC protein kinase alpha RAC-PK alpha

  • RAC-PK-alpha

  • murine thymoma viral (v-akt) oncogene homolog 1

  • protein kinase B alpha

  • thymoma viral proto-oncogene 1

  • v-akt murine thymoma viral oncogene homolog 1

Akt1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Akt1 P47196 Gapdh Rattus norvegicus P04797
Anti Bait CoIP
20488185
Intra
Akt1 P47196 Smad3 Rattus norvegicus P84025
Anti Tag CoIP
16362038
Intra
Akt1 P47196 Smad2 Rattus norvegicus O70436
Anti Tag CoIP
16362038
Intra
Akt1 P47196 Smad2 Rattus norvegicus O70436
Anti Bait CoIP
16362038
Intra
Akt1 P47196 Nfkb1 Rattus norvegicus Q63369
Anti Bait CoIP
16642037
Intra
Akt1 P47196 Nfkb1 Rattus norvegicus Q63369
Anti Tag CoIP
16642037
Intra
Akt1 P47196 Nfkb1 Rattus norvegicus Q63369
Pull Down
16642037
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N21965 Thesinine Ligand / Unkown
HY-N17458 N-Acetyldehydroanonaine Ligand / Unkown
HY-119884 DC-120 Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Akt1 NCBI NCBI:207