Akt1-IN-8
Akt1-IN-8 (Compound JL18) is a potent and oral bioavailable (41%) inhibitor of AKT1 kinase, with an IC50 of 8.8 nM. Akt1-IN-8 exhibits significant antiproliferative effects against PC-3 prostate cancer cells, with an IC50 of 3.0 μM. Akt1-IN-8 can reduce phosphorylated GSK3β levels.
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- No. CAS: 2247688-87-3
- Fòrmula: C21H25Br2N7O
- Peso molecular:551.28
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Akt1 8.8 nM (IC50) |
Chemical Information
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No. CAS 2247688-87-3
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Peso molecular 551.28
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Fòrmula C21H25Br2N7O
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SMILES
O=C(C(CNC(C)C)C1=CC=C(C=C1)Br)N2CCN(CC2)C3=C4C(Br)=NNC4=NC=N3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Akt1-IN-8 Related Classifications
HY-173122 Related Classifications
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