2. Gene
  3. Mc4r - melanocortin 4 receptor Gene

Mc4r - melanocortin 4 receptor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 25635 | Gene type: protein coding

About Mc4r

Primary_assembly 18: 60,419,832-60,421,719 reverse strand.mRatBN7.2:CM026991.1

This gene has 1 transcript (splice variant), 231 orthologues, 18 paralogues and is associated with 44 phenotypes.

Summary

Enables Melanocortin Receptor activity and peptide hormone binding activity. Involved in several processes, including diet induced thermogenesis; negative regulation of feeding behavior; and regulation of grooming behavior. Located in nucleus and plasma membrane. Used to study obesity. Biomarker of obesity and sciatic neuropathy. Human ortholog(s) of this gene implicated in morbid obesity and obesity. Orthologous to human MC4R (melanocortin 4 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Mc4r Products(1)

mRNA Protein Name
NM_013099.3 NP_037231.1 melanocortin receptor 4

Mc4r Protein Structure

7tmA_MC4R

7tmA_MC4R: cd15353 (44 - 312)

7tmA_MC4R

7tmA_MC4R: cd15353 (45 - 71)

7tmA_MC4R

7tmA_MC4R: cd15353 (78 - 104)

7tmA_MC4R

7tmA_MC4R: cd15353 (121 - 151)

7tmA_MC4R

7tmA_MC4R: cd15353 (163 - 183)

7tmA_MC4R

7tmA_MC4R: cd15353 (188 - 217)

7tmA_MC4R

7tmA_MC4R: cd15353 (237 - 267)

7tmA_MC4R

7tmA_MC4R: cd15353 (280 - 305)

  • 0
  • 100
  • 200
  • 300
  • 332 a.a.
Protein Preferred Names Protein Names

melanocortin receptor 4

MC4-R

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-118930 MK-0493 Agonist 99.02% Phase 2
Pre-clinical Phase
Bioactive Molecules (15)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P0252 α-MSH Agonist 99.57% Unkown
HY-P0227 SHU 9119 99.95% Unkown
HY-P0097A Nonapeptide-1 acetate salt Antagonist 98.70% Unkown
HY-P0252A α-MSH TFA Agonist 98.79% Unkown
HY-10624 THIQ Agonist 98.11% Unkown
HY-P1215A HS024 TFA Antagonist 99.80% Unkown
HY-P1216A HS014 TFA Antagonist 99.87% Unkown
HY-110123 ML-00253764 hydrochloride Inhibitor 99.47% Unkown
HY-P2242A RO27-3225 TFA Agonist 98.94% Unkown
HY-P1213 JKC363 Antagonist 99.55% Unkown
HY-P1216 HS014 Antagonist / Unkown
HY-P0252B α-MSH free acid Agonist / Unkown
HY-P1213A JKC363 TFA Antagonist / Unkown
HY-P0097 Nonapeptide-1 Antagonist / Unkown
HY-P3561 Agouti-related Protein (AGRP) (83-132) Amide (human) Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mc4r NCBI NCBI:4160
Mus musculus Mc4r NCBI NCBI:17202