Bmp6 - bone morphogenetic protein 6 Gene

Also Known as VGR

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25644

Summary

Enables growth factor activity. Involved in several processes, including cellular response to mechanical stimulus; positive regulation of aldosterone secretion; and positive regulation of cell differentiation. Located in cytoplasm; extracellular space; and vesicle. Biomarker of anemia; brain ischemia; and colitis. Orthologous to human BMP6 (bone morphogenetic protein 6). [provided by Alliance of Genome Resources, Apr 2022]

Bmp6 Products (1)

mRNA Protein Name
NM_013107.2 NP_037239.1 bone morphogenetic protein 6 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables growth factor activity IDA
IDA: Inferred from direct assay
9168801 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
23198877 RGD
involved in ossification IDA
IDA: Inferred from direct assay
16761078 RGD
involved in osteoblast differentiation IEP
IEP: Inferred from expression pattern
11995934 RGD
involved in positive regulation of aldosterone secretion IDA
IDA: Inferred from direct assay
22538126 RGD
involved in positive regulation of chondrocyte differentiation IDA
IDA: Inferred from direct assay
23077084 RGD
involved in positive regulation of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
9202223 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
23198877 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
9202223 RGD
involved in response to iron ion IEP
IEP: Inferred from expression pattern
21859731 RGD
involved in response to magnesium ion IEP
IEP: Inferred from expression pattern
21736832 RGD
involved in response to retinoic acid IEP
IEP: Inferred from expression pattern
8385738 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
11245809 RGD
located in vesicle IDA
IDA: Inferred from direct assay
18758911 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

bone morphogenetic protein 6

  • BMP-6

  • VG-1-related protein

  • VGR-1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P991637 Exerenibart Inhibitor 98.00% Phase 2

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-16712 LDN-214117 Inhibitor 99.54% Unkown
HY-173149 CDD-2789 Inhibitor / Unkown
HY-118970 LG190155 / Unkown
HY-RS01541 BMP6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17946 Bmp6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24417 Bmp6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991881 KY1070 / Unkown
HY-P990974 Bezeotermin alfa / Unkown
HY-P991880 Anti-BMP6 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bmp6 NCBI NCBI:654