2. Gene
  3. Scn5a - sodium voltage-gated channel alpha subunit 5 Gene

Scn5a - sodium voltage-gated channel alpha subunit 5 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as SCAL; Nav1.5

Gene ID: 25665 | Gene type: protein coding

About Scn5a

Primary_assembly 8: 119,220,905-119,318,769 reverse strand.mRatBN7.2:CM026981.1

This gene has 3 transcripts (splice variants), 94 orthologues, 26 paralogues and is associated with 58 phenotypes. Restricted expression toward (RPKM 231.9).

Summary

Enables ankyrin binding activity; Fibroblast Growth Factor binding activity; and voltage-gated Sodium Channel activity involved in cardiac muscle cell action potential. Involved in several processes, including animal organ development; response to denervation involved in regulation of muscle adaptation; and sodium ion import across plasma membrane. Located in T-tubule and intercalated disc. Biomarker of brain ischemia and congestive heart failure. Human ortholog(s) of this gene implicated in heart conduction disease (multiple); intrinsic cardiomyopathy (multiple); and sudden infant death syndrome. Orthologous to human SCN5A (sodium voltage-gated channel alpha subunit 5). [provided by Alliance of Genome Resources, Apr 2022]

Scn5a Products(2)

mRNA Protein Name
NM_001160162.2 NP_001153634.2 sodium channel protein type 5 subunit alpha isoform 2
NM_013125.3 NP_037257.2 sodium channel protein type 5 subunit alpha isoform 1

Scn5a Protein Structure

Ion_trans

Ion_trans: pfam00520 (130 - 423)

Na_trans_cytopl

Na_trans_cytopl: pfam11933 (509 - 667)

Ion_trans

Ion_trans: pfam00520 (716 - 929)

Na_trans_assoc

Na_trans_assoc: pfam06512 (955 - 1202)

Ion_trans

Ion_trans: pfam00520 (1206 - 1481)

Na_channel_gate

Na_channel_gate: cd13433 (1473 - 1525)

Ion_trans

Ion_trans: pfam00520 (1530 - 1784)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2020 a.a.
Protein Preferred Names Protein Names

sodium channel protein type 5 subunit alpha

sodium channel protein cardiac muscle subunit alpha

sodium channel protein type V subunit alpha

sodium channel, voltage-gated, type 5, alpha subunit

sodium channel, voltage-gated, type V, alpha polypeptide

sodium channel, voltage-gated, type V, alpha subunit

voltage-gated sodium channel Nav1.5c

voltage-gated sodium channel subunit alpha Nav1.5

Related Agents

Approval
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0405 Bupivacaine 99.96% Yes
HY-B0405A Bupivacaine hydrochloride Inhibitor 99.89% Yes
HY-B0405AR Bupivacaine hydrochloride (Standard) Inhibitor / Unkown
Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0405S Bupivacaine-d9 / Unkown
HY-RS12541 SCN5A Human Pre-designed siRNA Set A / Unkown
HY-RS12542 Scn5a Mouse Pre-designed siRNA Set A / Unkown
HY-RS12543 Scn5a Rat Pre-designed siRNA Set A / Unkown
HY-W415121 Bupivacaine hydrochloride monohydrate Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Scn5a NCBI NCBI:6331