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Cat. No.: HY-FLW415121

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Bupivacaine hydrochloride solution

Bupivacaine hydrochloride solution is mainly composed of Bupivacaine hydrochloride monohydrate (HY-W415121). Bupivacaine hydrochloride monohydrate is a NMDA receptor inhibitor. Bupivacaine hydrochloride monohydrate can block sodium, L-calcium, and potassium channels. Bupivacaine hydrochloride monohydrate potently blocks SCN5A channels with the IC₅₀ of 69.5 μM. Bupivacaine hydrochloride monohydrate can be used for the research of chronic pain.

For research use only. We do not sell to patients.

CAS No.: 73360-54-0
Formula: C₁₈H₃₁ClN₂O₂
Molecular Weight:342.90

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Bupivacaine hydrochloride solution Chemical Structure

CAS No.: 73360-54-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All iGluR Isoforms :

All Sodium Channel Isoforms :

All Calcium Channel Isoforms :

Chemical Information

CAS No. 73360-54-0
Molecular Weight 342.90
Formula C₁₈H₃₁ClN₂O₂
SMILES

CCCCN1CCCCC1C(NC2=C(C)C=CC=C2C)=O.O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Meaghan A Paganelli, et al. Actions of Bupivacaine, a widely used local anesthetic, on NMDA receptor responses. J Neurosci. 2015 Jan 14;35(2):831-42. [Content Brief]

[2]. Alexander P Schwoerer, et al. A Comparative Analysis of Bupivacaine and Ropivacaine Effects on Human Cardiac SCN5A Channels. Anesth Analg. 2015 Jun;120(6):1226-34. [Content Brief]

[3]. Carsten Stoetzer, et al. Inhibition of Voltage-Gated Na⁺ Channels by Bupivacaine Is Enhanced by the Adjuvants Buprenorphine, Ketamine, and Clonidine. Reg Anesth Pain Med.Jul/Aug 2017;42(4):462-468. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
Chemical Information
Protocols
Purity & Documentation
References

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Bupivacaine hydrochloride solution

All iGluR Isoforms

All Sodium Channel Isoforms

All Calcium Channel Isoforms