Cckbr - cholecystokinin B receptor Gene

Also Known as Cck2r; Cholrec

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25706

About Cckbr

Primary_assembly 1: 159,771,733-159,814,881 forward strand.mRatBN7.2:CM026974.1

This gene has 3 transcripts (splice variants), 268 orthologues, 16 paralogues and is associated with 12 phenotypes. Restricted expression toward (RPKM 39.4).

Summary

Cholecystokinin was one of the first gastrointestinal peptides discovered in the mammalian brain. Cholecystokinin receptors are members of the G protein-coupled receptor superfamily, stimulating phosphatidylinositol turnover and intracellular calcium mobilization. This gene encodes a Cholecystokinin Receptor of the B subtype. These receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. [provided by RefSeq, Jul 2008]

Cckbr Products (1)

mRNA Protein Name
NM_013165.3 NP_037297.2 gastrin/cholecystokinin type B receptor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables gastrin receptor activity IMP
IMP: Inferred from mutant phenotype
1528881 RGD
Biological Process GO Annotation Evidence References Source
involved in ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
17226751 RGD
involved in behavioral defense response IMP
IMP: Inferred from mutant phenotype
17498673 RGD
involved in estrous cycle IDA
IDA: Inferred from direct assay
17045752 RGD
involved in histamine secretion IMP
IMP: Inferred from mutant phenotype
17531331 RGD
involved in positive regulation of behavioral fear response IMP
IMP: Inferred from mutant phenotype
12373548 RGD
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
17531331 RGD
involved in positive regulation of somatostatin secretion IMP
IMP: Inferred from mutant phenotype
19959964 RGD
involved in positive regulation of synaptic transmission IMP
IMP: Inferred from mutant phenotype
19386755 RGD
involved in positive regulation of synaptic transmission, GABAergic IMP
IMP: Inferred from mutant phenotype
17904218 RGD
involved in positive regulation of synaptic transmission, glutamatergic IMP
IMP: Inferred from mutant phenotype
18088282 RGD
involved in response to insulin IEP
IEP: Inferred from expression pattern
15161757 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cckbr Protein Structure

7tm_GPCRs

7tm_GPCRs: cl28897 (54 - 405)

7tm_GPCRs

7tm_GPCRs: cd14964 (56 - 80)

7tm_GPCRs

7tm_GPCRs: cd14964 (89 - 111)

7tm_GPCRs

7tm_GPCRs: cd14964 (127 - 149)

7tm_GPCRs

7tm_GPCRs: cd14964 (172 - 188)

7tm_GPCRs

7tm_GPCRs: cd14964 (215 - 238)

7tm_GPCRs

7tm_GPCRs: cd14964 (336 - 358)

7tm_GPCRs

7tm_GPCRs: cd14964 (373 - 398)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 452 a.a.
Protein Preferred Names Protein Names

gastrin/cholecystokinin type B receptor

  • CCK-B receptor

  • CCK-BR

  • CCK2 receptor

  • CCK2-R

  • cholecystokinin-2 receptor

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-A0261 Pentagastrin Agonist 99.97% Unkown
HY-A0261A Pentagastrin meglumine Agonist / Unkown

Clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Phase
HY-19445 Gastrazole Antagonist / Phase 3
HY-106840 L-365260 Antagonist 99.85% Phase 2
HY-14850 Sograzepide Antagonist 98.04% Phase 2
HY-17617 Nastorazepide Antagonist 99.95% Phase 2
HY-105257 Pranazepide Antagonist 99.81% Phase 2
HY-106347 Itriglumide Antagonist / Phase 2
HY-19290 S-0509 Antagonist / Phase 2

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1097 Gastrin I, human 99.93% Unkown
HY-P11540 CCKBR agonist-1 Agonist 98.48% Unkown
HY-111313 JNJ-26070109 Antagonist 99.25% Unkown
HY-129357 CCK-B Receptor Antagonist 2 Inhibitor 98.84% Unkown
HY-155205 GV150013X Antagonist 99.75% Unkown
HY-177506 FE100726 Agonist / Unkown
HY-186122 CCK2R agonist-1 Agonist / Unkown
HY-129810 PD 135158 Antagonist / Unkown
HY-177509 BBL454 Agonist / Unkown
HY-177508 BC264 Agonist / Unkown
HY-119127 TP-680 Antagonist / Unkown
HY-123434 PD-149164 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cckbr NCBI NCBI:887