AMBP - alpha-1-microglobulin/bikunin precursor Gene

Also Known as A1M; HCP; ITI; UTI; EDC1; HI30; ITIL; IATIL; ITILC

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 259

About AMBP

Cytogenetic location: 9q32 Genomic coordinates (GRCh38): 9:114,060,127-114,078,300 (from NCBI)

This gene has 4 transcripts (splice variants), 194 orthologues and 13 paralogues. Restricted expression toward liver (RPKM 2536.6).

Summary

This gene encodes a complex glycoprotein secreted in plasma. The precursor is proteolytically processed into distinct functioning proteins: alpha-1-microglobulin, which belongs to the superfamily of lipocalin transport proteins and may play a role in the regulation of inflammatory processes, and bikunin, which is a urinary trypsin inhibitor belonging to the superfamily of Kunitz-type Protease Inhibitors and plays an important role in many physiological and pathological processes. This gene is located on chromosome 9 in a cluster of lipocalin genes. [provided by RefSeq, Jul 2008]

AMBP Products (1)

mRNA Protein Name
NM_001633.4 NP_001624.1 protein AMBP preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables IgA binding IDA
IDA: Inferred from direct assay
9183005 GOA
enables antioxidant activity IDA
IDA: Inferred from direct assay
22096585 GOA
enables carbohydrate binding EXP
EXP: Inferred from Experiment
7513643 GOA
enables chondroitin sulfate binding IDA
IDA: Inferred from direct assay
16873769 GOA
enables collagen fibril binding IDA
IDA: Inferred from direct assay
22096585 GOA
enables heme binding IDA
IDA: Inferred from direct assay
11877257 GOA
enables oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor IDA
IDA: Inferred from direct assay
15683711 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9183005 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
9183005 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
11883904 GOA
enables serine-type endopeptidase inhibitor activity IDA
IDA: Inferred from direct assay
10480954 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in cellular oxidant detoxification IDA
IDA: Inferred from direct assay
22096585 GOA
involved in cellular response to reactive oxygen species IDA
IDA: Inferred from direct assay
23157686 GOA
involved in cytochrome c metabolic process IDA
IDA: Inferred from direct assay
15683711 GOA
involved in hemoglobin metabolic process IDA
IDA: Inferred from direct assay
15683711 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in extracellular space IDA
IDA: Inferred from direct assay
15683711 GOA
located in matrix side of mitochondrial inner membrane IDA
IDA: Inferred from direct assay
23157686 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
12817471 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AMBP Protein Structure

Lipocalin

Lipocalin: Lipocalin / cytosolic fatty-acid binding protein family (42 - 184)

Kunitz_BPTI

Kunitz_BPTI: Kunitz/Bovine pancreatic trypsin inhibitor domain (231 - 282)

Kunitz_BPTI

Kunitz_BPTI: Kunitz/Bovine pancreatic trypsin inhibitor domain (286 - 338)

  • 0
  • 100
  • 200
  • 300
  • 352 a.a.
Protein Preferred Names Protein Names

protein AMBP

  • bikunin

AMBP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
AMBP P02760 CTSB Homo sapiens P07858
IF
16364318
Intra
AMBP P02760 FHL3 Homo sapiens Q13643
Validated Y2H
25416956
Intra
AMBP P02760 FHL3 Homo sapiens Q13643
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant AMBP Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P7489 Alpha 1-Microglobulin Protein, Human (HEK293, His) P02760 (G20-V203) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75476 Alpha 1-Microglobulin Protein, Human (P.pastoris, His) P02760 (A206-L348) ≥ 85%, as determined by reducing SDS-PAGE.

AMBP Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P83624 AMBP Antibody (YA3369) WB, IHC-P Human

Related Diseases

Diseases Alias
Hepatitis E
Nephrolithiasis, Calcium Oxalate

  • Kidney Stones

  • Calculus Of Kidney

  • Kidney Calculi

  • Nephrolithiasis

  • Renal Calculi

  • Calcium Oxalate Urolithiasis

  • CAON

  • Urolithiasis, Calcium Oxalate

  • Calcium Oxalate Nephrolithiasis

  • Kidney Stone

  • Nephrolith

  • Renal Calculus

  • Urinary Stones

  • Renal Stone

  • Calculus, Kidney

  • Calculus, Renal

  • Renal Lithiasis

  • Renal Stones

  • Urolithiasis

  • Renal Calculus Or Stone

  • Stone In Kidney

  • Nephritic Calculus

  • Multiple Kidney Calculi

  • Multiple Kidney Calculus

  • Nephrolithiasis Nos

  • Pelvic Nephrolithiasis

  • Pelviolithiasis

  • Pelvis Nephrolithiasis
Pyelonephritis
Urolithiasis
Obstructive Nephropathy

  • Con

  • Congenital Obstructive Nephropathy

  • Nephropathy Obstructive
Kidney Disease

  • Renal Failure

  • Kidney Failure

  • Kidney Diseases

  • Nephropathy

  • Abnormality Of The Kidney

  • Impaired Renal Function Disease

  • Renal Anomaly

  • Kidney Dysfunction

  • Renal Disease

  • Nephropathies

  • Renal Failure Adverse Event

  • Abnormal Renal Function
Type 1 Diabetes Mellitus

  • Diabetes Mellitus, Insulin-Dependent

  • Diabetes Mellitus Type 1

  • IDDM

  • Type 1 Diabetes

  • Insulin-Dependent Diabetes Mellitus

  • T1D

  • Juvenile-Onset Diabetes

  • Jod

  • Diabetes Mellitus, Type 1

  • Diabetes Mellitus, Insulin-Dependent-1

  • Type I Diabetes Mellitus

  • Autoimmune Diabetes

  • Juvenile Diabetes

  • Juvenile-Onset Diabetes Mellitus

  • Diabetes, Insulin Dependent

  • Insulin-Dependent Diabetes Mellitus-1

  • Diabetes Mellitus Insulin-Dependent

  • Diabetes Autoimmune

  • Diabetes Mellitus, Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 1, Susceptibility To

  • Diabetes Type 1

  • Type I Diabetes

  • Diabetes, Autoimmune

  • T1dm - [Type 1 Diabetes Mellitus]

  • Iddm - [Insulin Dependent Diabetes Mellitus]

  • Type 1 Iddm

  • Juvenile Diabetes Mellitus Without Compications

  • Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications

  • Juvenile-Onset Diabetes Mellitus Without Compications

  • Ketosis-Prone Diabetes Mellitus Without Compications

  • Juvenile-Onset-Type Diabetes Mellitus Without Compications
Fanconi Syndrome

  • Infantile Nephropathic Cystinosis

  • Adult Fanconi Syndrome

  • Congenital Fanconi Syndrome

  • De Toni-Fanconi Syndrome

  • Fanconi-De Toni Syndrome

  • Lignac-Fanconi Syndrome

  • Fanconi Renotubular Syndrome

  • Primary Fanconi Renotubular Syndrome

  • De Toni-Debre-Fanconi Syndrome

  • Adult Fanconi Anemia

  • Detoni Fanconi Syndrome

  • Fanconi-De-Toni Syndrome

  • Primary Fanconi Syndrome

  • Detoni-Debre-Fanconi Syndrome

  • Primary Fanconi Renal Syndrome

  • Fanconi Anemia

  • Cystinosis, Infantile Nephropathic

  • Fanconi-Bickel Syndrome

  • Renal Fanconi Syndrome

  • Lowe-Bickel Syndrome
Dermatitis, Atopic, 5

  • ATOD5

  • Atopic Dermatitis 5

  • Dermatitis, Atopic, Susceptibility To, 5

  • Dermatitis, Atopic 5
Glomerulonephritis

  • Bright'S Disease
Nephrotic Syndrome

  • Finnish Congenital Nephrotic Syndrome

  • Ns - [Nephrotic Syndrome]

  • Nephrosis Syndrome

  • Nephrosis Nos

  • Glomerular Lesion Nephrosis
Vesicoureteral Reflux

  • Vesico-Ureteral Reflux
Hydronephrosis

  • Stricture Of Ureteropelvic Junction With Hydronephrosis

  • Hydronephrosis With Ureteral Stricture, Not Elsewhere Classified
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Cancer Of The Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Acute Kidney Failure

  • Acute Renal Failure

  • Acute Kidney Injury

  • Renal Failure Acute

  • Kidney Failure, Acute

  • Pre-Renal Acute Kidney Injury

  • Nontraumatic Acute Kidney Injury

  • Aki - [Acute Kidney Injury]

  • Arf - [Acute Kidney Failure]

  • Acute Kidney Disease

  • Acute Kidney Impairment

  • Acute Ischaemic Renal Failure

  • Acute Hypoxic Kidney Failure

  • Acute Kidney Shutdown

  • Acute Renal Oedema

  • Acute Renal Impairment

  • Acute Kidney Collapse

  • Acute Necrotising Kidney

  • Acute Renal Suppression
Malaria

  • Malaria, Susceptibility To

  • Malaria, Resistance To

  • Malaria, Cerebral

  • Cerebral Malaria

  • Malaria, Severe, Susceptibility To

  • Malaria, Severe, Resistance To

  • Malaria, Cerebral, Susceptibility To

  • Induced Malaria

  • Malaria, Vivax, Protection Against

  • Malaria, Severe

  • Malaria, Cerebral, Reduced Risk Of

  • Malaria, Protection Against

  • Resistance To Malaria Due To G6pd Deficiency

  • Malaria Due To G6pd Deficiency

  • Malarial Encephalitis

  • CM

  • Malaria Cerebral

  • Susceptibility To Malaria

  • Acute Pernicious Fever

  • Aestivo-Autumnal Fever

  • Aestivo Autumnal Malaria

  • Chagres Fever

  • Continued Malaria Fever

  • Estivo-Autumnal Fever

  • Estivo-Autumnal Malaria

  • Estivo-Autumnal Malarial Fever

  • Falciparum Fever

  • Malignant Tertian Fever

  • Malignant Tertian Malaria

  • Pernicious Intermittent Fever

  • Pernicious Malaria

  • Quotidian Malaria

  • Subtertian Fever

  • Subtertian Malaria Fever

  • Subtertian Malignant Tertian Malaria

  • Tropical Malaria

  • Algid Malaria

  • Bilious Haemoglobinuric Fever

  • Black Water Fever

  • Blackwater Fever

  • Malarial Blackwater Fever

  • Severe Malarial Falciparum

  • West African Fever

  • Malarial Haematinuria

  • Haemoglobinuric Fever

  • Haemoglobinuric Malaria

  • Severe Plasmodium Falciparum Malaria

  • Malarial Haemoglobinuria

  • Malarial Haematuria

  • Falciparum Malaria [Malignant Tertian]

  • Malaria Tropica

  • Malarial Shock

  • Chagres Virus Disease

  • Malignant Malaria

  • Mtm - [Malignant Tertian Malaria]

  • Tm -[Malignant Tertian Malaria]

  • Panama Fever

  • St - [Subtertian Malaria]

  • Malarial Quotidian

  • Benign Tertian Malaria

  • Tertian Ague

  • Vivax Fever

  • Plasmodium Vivax Malaria Nos

  • Btm - [Benign Tertian Malaria]

  • Bt - [Benign Tertian Malaria]

  • Vivax Malaria

  • Benign Tertian Vivax Malaria

  • Tertian Malaria

  • Quartan Malaria

  • Quartan Ague

  • Quartan Fever

  • Plasmodium Malariae Malaria Nos

  • Quartan Malarial

  • Malaria By Plasmodium Malariae

  • Malariae Malaria

  • Ovale Tertian Malaria

  • Plasmodium Ovale Fever

  • Malaria Fever By Plasmodium Ovale

  • Ovale Malaria

  • Malaria By Plasmodium Ovale

  • Malarial Ovale

  • Marsh Fever

  • Remittent Congestive Fever

  • Coastal Fever

  • Remittent Gastric Fever

  • Miasmatic Fever

  • Congestive Remittent Fever

  • Intermittent Fever

  • Jungle Fever

  • Paludism

  • Cameroon Fever

  • Ague

  • Corsican Fever

  • Intermittent Bilious Fever

  • Disease Due To Plasmodiidae

  • Malarial Fever

  • Plasmodiosis

  • Remittent Fever

  • Roman Fever

  • Malaria Fever Nos

  • Malaria Nos

  • Paludal Fever

  • Clinically Diagnosed Malaria

  • Clinically Diagnosed Malaria Without Parasitological Confirmation

  • Congestive Fever

  • Malarial Cachexia

  • Marsh Cachexia

  • Paludal Cachexia

  • Recurrent Malaria

  • Remittent Malaria
Distal Renal Tubular Acidosis

  • Classic Rta

  • Familial Distal Primary Acidosis

  • Renal Tubular Acidosis Type 1

  • Drta

  • Renal Tubular Acidosis, Distal
Diabetes Mellitus

  • Diabetes
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS00642 AMBP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17531 Ambp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23988 Ambp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris AMBP VGNC VGNC:51697
Mus musculus AMBP MGD MGI:88002
Macaca mulatta AMBP VGNC VGNC:103238
Rattus norvegicus AMBP RGD RGD:2102
Others AMBP NCBI