REXO2 - RNA exonuclease 2 Gene

Also Known as RFN; SFN; REX2; CGI-114

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 25996

About REXO2

Cytogenetic location: 11q23.2 Genomic coordinates (GRCh38): 11:114,439,467-114,450,279 (from NCBI)

This gene has 19 transcripts (splice variants) and 214 orthologues. Ubiquitous expression in heart (RPKM 41.6), kidney (RPKM 38.9) and 25 other tissues.

Summary

This gene encodes a 3'-to-5' exonuclease specific for small (primarily 5 nucleotides or less in length) single-stranded RNA and DNA oligomers. This protein may have a role in DNA repair, replication, and recombination, and in RNA processing and degradation. It may also be involved in resistance of human cells to UV-C-induced cell death through its role in the DNA repair process. [provided by RefSeq, Nov 2011]

REXO2 Products (1)

mRNA Protein Name
NM_015523.4 NP_056338.2 oligoribonuclease, mitochondrial precursor
Molecular Function GO Annotation Evidence References Source
enables 3'-5' exonuclease activity IDA
IDA: Inferred from direct assay
10851236 GOA
enables 3'-5' exonuclease activity IMP
IMP: Inferred from mutant phenotype
23741365 GOA
enables 3'-5'-DNA exonuclease activity IDA
IDA: Inferred from direct assay
31588022 GOA
enables 3'-5'-RNA exonuclease activity IDA
IDA: Inferred from direct assay
31588022 GOA
enables 3'-5'-RNA exonuclease activity IMP
IMP: Inferred from mutant phenotype
30926754 GOA
enables magnesium ion binding IDA
IDA: Inferred from direct assay
30926754 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within nucleobase-containing compound metabolic process IDA
IDA: Inferred from direct assay
10851236 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
32365187 GOA
located in mitochondrial intermembrane space IDA
IDA: Inferred from direct assay
23741365 GOA
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
23741365 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
32365187 GOA
located in nucleus IDA
IDA: Inferred from direct assay
32365187 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

REXO2 Protein Structure

RNase_T

RNase_T: Exonuclease (44 - 206)

  • 0
  • 100
  • 200
  • 237 a.a.
Protein Preferred Names Protein Names

oligoribonuclease, mitochondrial

  • REX2, RNA exonuclease 2 homolog

Related Diseases

Diseases Alias
Gallbladder Melanoma
  • Malignant Melanoma Of Gallbladder

Noonan Syndrome 1
  • Noonan Syndrome

  • NS1

  • Male Turner Syndrome

  • Female Pseudo-Turner Syndrome

  • Turner Phenotype With Normal Karyotype

  • Noonan Syndrome With Pigmented Villonodular Synovitis

  • Turner'S Phenotype, Karyotype Normal

  • Familial Turner Syndrome

  • Noonan'S Syndrome

  • Noonan-Ehmke Syndrome

  • Ns

  • Pseudo-Ullrich-Turner Syndrome

  • Turner Syndrome In Female With X Chromosome

  • Turner-Like Syndrome

  • Ullrich-Noonan Syndrome

  • Noonan-Like/Multiple Giant Cell Lesion Syndrome

  • Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

  • Pterygium Colli Syndrome

  • Noonan Syndrome, Type 1

  • Turner Syndrome, Male

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus REXO2 VGNC VGNC:64581
Macaca mulatta REXO2 VGNC VGNC:76757
Mus musculus REXO2 MGD MGI:1888981
Rattus norvegicus REXO2 RGD RGD:1304874
Canis familiaris REXO2 VGNC VGNC:45490
Bos taurus REXO2 VGNC VGNC:33884
Others REXO2 NCBI