REXO2 - RNA exonuclease 2 Gene
Also Known as RFN; SFN; REX2; CGI-114
Species: Homo sapiens
About REXO2
This gene has 19 transcripts (splice variants) and 214 orthologues. Ubiquitous expression in heart (RPKM 41.6), kidney (RPKM 38.9) and 25 other tissues.
Summary
This gene encodes a 3'-to-5' exonuclease specific for small (primarily 5 nucleotides or less in length) single-stranded RNA and DNA oligomers. This protein may have a role in DNA repair, replication, and recombination, and in RNA processing and degradation. It may also be involved in resistance of human cells to UV-C-induced cell death through its role in the DNA repair process. [provided by RefSeq, Nov 2011]
REXO2 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_015523.4 | NP_056338.2 | oligoribonuclease, mitochondrial precursor |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables 3'-5' exonuclease activity |
IDA
IDA: Inferred from direct assay
|
10851236 | GOA |
| enables 3'-5' exonuclease activity |
IMP
IMP: Inferred from mutant phenotype
|
23741365 | GOA |
| enables 3'-5'-DNA exonuclease activity |
IDA
IDA: Inferred from direct assay
|
31588022 | GOA |
| enables 3'-5'-RNA exonuclease activity |
IDA
IDA: Inferred from direct assay
|
31588022 | GOA |
| enables 3'-5'-RNA exonuclease activity |
IMP
IMP: Inferred from mutant phenotype
|
30926754 | GOA |
| enables magnesium ion binding |
IDA
IDA: Inferred from direct assay
|
30926754 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| acts upstream of or within nucleobase-containing compound metabolic process |
IDA
IDA: Inferred from direct assay
|
10851236 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in cytoplasm |
IDA
IDA: Inferred from direct assay
|
32365187 | GOA |
| located in mitochondrial intermembrane space |
IDA
IDA: Inferred from direct assay
|
23741365 | GOA |
| located in mitochondrial matrix |
IDA
IDA: Inferred from direct assay
|
23741365 | GOA |
| located in mitochondrion |
IDA
IDA: Inferred from direct assay
|
32365187 | GOA |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
32365187 | GOA |
REXO2 Protein Structure
RNase_T: Exonuclease (44 - 206)
- 0
- 100
- 200
- 237 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
oligoribonuclease, mitochondrial |
|
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Gallbladder Melanoma |
|
|
| Noonan Syndrome 1 |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Felis catus | REXO2 | VGNC | VGNC:64581 |
| Macaca mulatta | REXO2 | VGNC | VGNC:76757 |
| Mus musculus | REXO2 | MGD | MGI:1888981 |
| Rattus norvegicus | REXO2 | RGD | RGD:1304874 |
| Canis familiaris | REXO2 | VGNC | VGNC:45490 |
| Bos taurus | REXO2 | VGNC | VGNC:33884 |
| Others | REXO2 | NCBI |