Mapk8 - mitogen-activated protein kinase 8 Gene

Also Known as JNK; JNK1; Prkm8; SAPK1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 26419

About Mapk8

Chromosome 14: 33,099,855-33,169,115 reverse strand.GRCm39:CM001007.3

This gene has 11 transcripts (splice variants), 291 orthologues, 19 paralogues and is associated with 38 phenotypes. Broad expression in CNS E18 (RPKM 19.1), CNS E14 (RPKM 18.4) and 26 other tissues.

Summary

Enables JUN kinase activity and protein serine/threonine/tyrosine kinase activity. Involved in several processes, including JNK cascade; generation of neurons; and positive regulation of cellular protein metabolic process. Acts upstream of or within several processes, including cellular response to nitric oxide; positive regulation of determination of dorsal identity; and protein phosphorylation. Located in several cellular components, including basal dendrite; mitochondrion; and podosome. Is expressed in several structures, including central nervous system; genitourinary system; oral region epithelium; sensory organ; and skin. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm; chronic mucocutaneous candidiasis; colorectal adenoma; rectal benign neoplasm; and type 2 diabetes mellitus. Orthologous to human MAPK8 (mitogen-activated protein kinase 8). [provided by Alliance of Genome Resources, Apr 2022]

Mapk8 Products (4)

mRNA Protein Name
NM_001310454.1 NP_001297383.1 mitogen-activated protein kinase 8 isoform 3
NM_001310452.1 NP_001297381.1 mitogen-activated protein kinase 8 isoform 2
NM_001310453.1 NP_001297382.1 mitogen-activated protein kinase 8 isoform 4
NM_016700.4 NP_057909.1 mitogen-activated protein kinase 8 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables JUN kinase activity IDA
IDA: Inferred from direct assay
10811224 MGI
enables kinase activity IDA
IDA: Inferred from direct assay
12808090 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10471813 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
24889144 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
24127566 MGI
enables protein serine/threonine/tyrosine kinase activity IMP
IMP: Inferred from mutant phenotype
29153991 MGI
Biological Process GO Annotation Evidence References Source
involved in JNK cascade IDA
IDA: Inferred from direct assay
10811224 MGI
acts upstream of or within JUN phosphorylation IMP
IMP: Inferred from mutant phenotype
14967141 MGI
acts upstream of apoptotic signaling pathway IGI
IGI: Inferred from genetic interaction
16458303 MGI
acts upstream of or within cellular response to biotic stimulus IMP
IMP: Inferred from mutant phenotype
23262141 MGI
acts upstream of or within cellular response to hydrogen peroxide IDA
IDA: Inferred from direct assay
20808772 MGI
acts upstream of or within cellular response to nitric oxide IMP
IMP: Inferred from mutant phenotype
18007661 MGI
involved in dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
16000625 MGI
involved in energy homeostasis IDA
IDA: Inferred from direct assay
36977414 MGI
involved in integrin-mediated signaling pathway IDA
IDA: Inferred from direct assay
36812915 MGI
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
17284179 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
17284179 MGI
involved in neuron migration IMP
IMP: Inferred from mutant phenotype
21297631 MGI
acts upstream of or within ossification IMP
IMP: Inferred from mutant phenotype
15820682 MGI
acts upstream of or within peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
24889144 MGI
acts upstream of or within peptidyl-threonine phosphorylation IMP
IMP: Inferred from mutant phenotype
14967141 MGI
involved in positive regulation of NLRP3 inflammasome complex assembly IDA
IDA: Inferred from direct assay
28943315 MGI
acts upstream of or within positive regulation of apoptotic signaling pathway IGI
IGI: Inferred from genetic interaction
16458303 MGI
acts upstream of or within positive regulation of determination of dorsal identity IDA
IDA: Inferred from direct assay
18316368 MGI
acts upstream of or within positive regulation of podosome assembly IMP
IMP: Inferred from mutant phenotype
24127566 MGI
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
29153991 MGI
involved in positive regulation of protein ubiquitination IMP
IMP: Inferred from mutant phenotype
29153991 MGI
acts upstream of or within programmed necrotic cell death IMP
IMP: Inferred from mutant phenotype
18007661 MGI
acts upstream of or within protein localization to tricellular tight junction IMP
IMP: Inferred from mutant phenotype
24889144 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
15767678 MGI
involved in protein phosphorylation IMP
IMP: Inferred from mutant phenotype
22441692 MGI
involved in regulation of circadian rhythm IMP
IMP: Inferred from mutant phenotype
22441692 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
19289495 MGI
acts upstream of or within response to cadmium ion IGI
IGI: Inferred from genetic interaction
16458303 MGI
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
17284179 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
17284179 MGI
located in axon IMP
IMP: Inferred from mutant phenotype
22683681 MGI
located in basal dendrite IMP
IMP: Inferred from mutant phenotype
22683681 MGI
is active in cytoplasm IDA
IDA: Inferred from direct assay
29078390 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
15030387 MGI
located in cytoplasm IMP
IMP: Inferred from mutant phenotype
29153991 MGI
located in cytosol IDA
IDA: Inferred from direct assay
11884367 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
11884367 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
29078390 MGI
located in nucleus IDA
IDA: Inferred from direct assay
15030387 MGI
located in podosome IDA
IDA: Inferred from direct assay
24127566 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mapk8 Protein Structure

STKc_JNK

STKc_JNK: cd07850 (24 - 359)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 427 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase 8

  • JNK1 beta1 protein kinase

  • MAP kinase 8

  • MAPK 8

  • c-Jun N-terminal kinase 1

  • protein kinase mitogen-activated 8

  • stress-activated protein kinase JNK1

Mapk8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Mapk8 Q91Y86 Jun Mus musculus P05627
Protein Kinase Assay
17255944
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N2593 Isorhapontigenin 99.82% Unkown
HY-128448 Carmoisine 98.66% Unkown
HY-148061 DB1113 99.86% Unkown
HY-148063 DB0614 99.92% Unkown
HY-RS08121 MAPK8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08123 Mapk8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-183319 Anticancer agent 320 / Unkown
HY-RS08122 Mapk8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08124 MAPK8IP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08125 MAPK8IP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08126 MAPK8IP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22065 Mapk8ip1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mapk8 NCBI NCBI:5599