GDI2 - GDP dissociation inhibitor 2 Gene

Also Known as RABGDIB; HEL-S-46e

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2665

About GDI2

Cytogenetic location: 10p15.1 Genomic coordinates (GRCh38): 10:5,765,223-5,813,434 (from NCBI)

This gene has 9 transcripts (splice variants), 252 orthologues and 3 paralogues. Ubiquitous expression in lymph node (RPKM 104.1), appendix (RPKM 84.4) and 25 other tissues.

Summary

GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the Ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

GDI2 Products (2)

mRNA	Protein	Name
NM_001115156.2	NP_001108628.1	rab GDP dissociation inhibitor beta isoform 2
NM_001494.4	NP_001485.2	rab GDP dissociation inhibitor beta isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11809807	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of cilium assembly	IMP IMP: Inferred from mutant phenotype	25860027	GOA
involved in negative regulation of protein localization to cilium	IMP IMP: Inferred from mutant phenotype	25860027	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GDI2 Protein Structure

GDI

0
100
200
300
400
445 a.a.

Protein Preferred Names	Protein Names
rab GDP dissociation inhibitor beta	GDI-2

GDI2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GDI2	P50395	RAB1A	Homo sapiens	P62820-1	Pull Down	20176951
Cross	GDI2	P50395	Dzip1	Mus musculus	Q8BMD2-1	Pull Down	25860027
Cross	GDI2	P50395	Dzip1	Mus musculus	Q8BMD2-1	Anti Tag CoIP	25860027
Intra	GDI2	P50395	RAB24	Homo sapiens	Q969Q5	Anti Tag CoIP	35271311
Cross	GDI2	P50395	Rab8a	Mus musculus	P55258	Pull Down	25860027
Cross	GDI2	P50395	Dzip1	Mus musculus	Q8BMD2	Pull Down	25860027
Intra	GDI2	P50395	RAB4A	Homo sapiens	P20338	Anti Tag CoIP	35271311
Intra	GDI2	P50395	RAB4A	Homo sapiens	P20338	FRET	19570034
Cross	GDI2	P50395	Rab10	Mus musculus	P61027	Confocal	19570034
Cross	GDI2	P50395	Rab10	Mus musculus	P61027	FRET	19570034
Cross	GDI2	P50395	Rab10	Mus musculus	P61027	Anti Tag CoIP	19570034

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GDI2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71737	GDI2 Protein, Human (P.pastoris, His)	P50395 (M1-D445)	≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-156242	BQZ-485	Inducer	/	Unkown
HY-156243	GDI2-IN-1		/	Unkown
HY-156244	PROTAC GDI2 Degrader-1	Inducer	/	Unkown
HY-175690	cIAP1 ligand 6		/	Unkown
HY-RS05360	GDI2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20740	Gdi2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27252	Gdi2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GDI2	MGD	MGI:99845
Rattus norvegicus	GDI2	RGD	RGD:61802
Bos taurus	GDI2	VGNC	VGNC:29308
Canis familiaris	GDI2	VGNC	VGNC:41165
Felis catus	GDI2	VGNC	VGNC:62507
Macaca mulatta	GDI2	VGNC	VGNC:72911
Others	GDI2	NCBI