Rheb - Ras homolog, mTORC1 binding Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 26954

Summary

Enables GDP binding activity; GTP binding activity; and GTPase activity. Involved in regulation of postsynapse organization and small GTPase mediated signal transduction. Located in dendrite and neuronal cell body. Is active in glutamatergic synapse. Orthologous to human RHEB (Ras homolog, mTORC1 binding). [provided by Alliance of Genome Resources, Apr 2022]

Rheb Products (1)

mRNA Protein Name
NM_013216.1 NP_037348.1 GTP-binding protein Rheb

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GDP binding IDA
IDA: Inferred from direct assay
16354680 RGD
enables GTP binding IDA
IDA: Inferred from direct assay
16354680 RGD
enables GTPase activity IDA
IDA: Inferred from direct assay
16354680 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15150271 RGD
Biological Process GO Annotation Evidence References Source
involved in regulation of postsynapse organization IDA
IDA: Inferred from direct assay
24889507 RGD
involved in regulation of postsynapse organization IMP
IMP: Inferred from mutant phenotype
24889507 RGD
involved in small GTPase-mediated signal transduction IDA
IDA: Inferred from direct assay
16354680 RGD
Cellular Component GO Annotation Evidence References Source
located in dendrite IDA
IDA: Inferred from direct assay
15525761 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
24889507 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
24889507 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
15525761 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

GTP-binding protein Rheb

  • Ras homolog enriched in brain

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-14530 Pelitrexol 98.07% Phase 2

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-124798 Rheb inhibitor NR1 Inhibitor 99.26% Unkown
HY-172423 Darlifarnib Inhibitor / Unkown
HY-17654 BIEGi-1 Inhibitor / Unkown
HY-RS11942 RHEB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17646 Rheb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24106 Rheb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rheb NCBI NCBI:6009