Chd5 - chromodomain helicase DNA binding protein 5 Gene

Also Known as CHD-5; 4930532L22Rik; B230399N07Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 269610

Summary

Enables H3K27me3 modified histone binding activity and histone deacetylase binding activity. Involved in several processes, including cerebral cortex neuron differentiation; positive regulation of signal transduction by p53 class mediator; and spermatogenesis, exchange of chromosomal proteins. Located in heterochromatin and nucleus. Part of NuRD complex. Is expressed in central nervous system and dorsal root ganglion. Orthologous to human CHD5 (chromodomain helicase DNA binding protein 5). [provided by Alliance of Genome Resources, Apr 2022]

Chd5 Products (3)

mRNA Protein Name
NM_001081376.1 NP_001074845.1 chromodomain-helicase-DNA-binding protein 5 isoform 1
NM_001369243.1 NP_001356172.1 chromodomain-helicase-DNA-binding protein 5 isoform 3
NM_029216.2 NP_083492.2 chromodomain-helicase-DNA-binding protein 5 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables H3K27me3 modified histone binding IDA
IDA: Inferred from direct assay
23948251 MGI
enables histone binding IDA
IDA: Inferred from direct assay
23318260 MGI
enables histone deacetylase binding IPI
IPI: Inferred from physical interaction
21931736 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
21931736 MGI
Biological Process GO Annotation Evidence References Source
involved in cerebral cortex neuron differentiation IMP
IMP: Inferred from mutant phenotype
23948251 MGI
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
17289567 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
23318260 MGI
involved in positive regulation of signal transduction by p53 class mediator IMP
IMP: Inferred from mutant phenotype
17289567 MGI
involved in regulation of cell differentiation IMP
IMP: Inferred from mutant phenotype
23318260 MGI
involved in sperm DNA condensation IMP
IMP: Inferred from mutant phenotype
24252660 MGI
Cellular Component GO Annotation Evidence References Source
part of NuRD complex IDA
IDA: Inferred from direct assay
21931736 MGI
located in heterochromatin IDA
IDA: Inferred from direct assay
23318260 MGI
located in nucleus IDA
IDA: Inferred from direct assay
23948251 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

chromodomain-helicase-DNA-binding protein 5

  • ATP-dependent helicase CHD5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-118780 CHD-5 Antagonist 98.0% Unkown
HY-RS05373 GET1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02610 CHD5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02611 CHD6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07062 KALRN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18344 Chd5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24823 Chd5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Chd5 NCBI NCBI:26038