Mc2r - melanocortin 2 receptor Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 282839

About Mc2r

Primary_assembly 18: 62,004,948-62,015,488 reverse strand.mRatBN7.2:CM026991.1

This gene has 1 transcript (splice variant), 178 orthologues, 18 paralogues and is associated with 10 phenotypes. Biased expression in Adrenal (RPKM 393.7) and Muscle (RPKM 25.).

Summary

Predicted to enable G protein-coupled receptor activity. Involved in placenta development. Located in cytoplasm and plasma membrane. Biomarker of toxic shock syndrome. Human ortholog(s) of this gene implicated in West syndrome and glucocorticoid deficiency 1. Orthologous to human MC2R (melanocortin 2 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Mc2r Products (1)

mRNA Protein Name
NM_001100491.1 NP_001093961.1 adrenocorticotropic hormone receptor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in placenta development IEP
IEP: Inferred from expression pattern
15781985 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mc2r Protein Structure

7tmA_MC2R_ACTH_R

7tmA_MC2R_ACTH_R: cd15350 (24 - 286)

7tmA_MC2R_ACTH_R

7tmA_MC2R_ACTH_R: cd15350 (25 - 51)

7tmA_MC2R_ACTH_R

7tmA_MC2R_ACTH_R: cd15350 (58 - 84)

7tmA_MC2R_ACTH_R

7tmA_MC2R_ACTH_R: cd15350 (102 - 132)

7tmA_MC2R_ACTH_R

7tmA_MC2R_ACTH_R: cd15350 (144 - 164)

7tmA_MC2R_ACTH_R

7tmA_MC2R_ACTH_R: cd15350 (169 - 198)

7tmA_MC2R_ACTH_R

7tmA_MC2R_ACTH_R: cd15350 (211 - 241)

7tmA_MC2R_ACTH_R

7tmA_MC2R_ACTH_R: cd15350 (254 - 279)

  • 0
  • 100
  • 200
  • 296 a.a.
Protein Preferred Names Protein Names

adrenocorticotropic hormone receptor

  • melanocortin 2 receptor (adrenocorticotropic hormone)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1477 Adrenocorticotropic hormone (1-39), rat Agonist 99.31% Unkown
HY-P1477A Adrenocorticotropic hormone (1-39), rat TFA Agonist 99.84% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mc2r NCBI NCBI:4158