CISD3 - CDGSH iron sulfur domain 3 Gene

Also Known as MiNT; Miner2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 284106

About CISD3

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:38,730,341-38,735,605 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele, 94 orthologues and 2 paralogues. Ubiquitous expression in kidney (RPKM 15.7), small intestine (RPKM 14.3) and 25 other tissues.

Summary

CISD3 is a member of the CDGSH domain-containing family, which may play a role in regulating electron transport and Oxidative Phosphorylation (Wiley et al., 2007 [PubMed 17376863]).[supplied by OMIM, Apr 2008]

CISD3 Products (1)

mRNA	Protein	Name
NM_001136498.2	NP_001129970.1	CDGSH iron-sulfur domain-containing protein 3, mitochondrial precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 2 iron, 2 sulfur cluster binding	IDA IDA: Inferred from direct assay	29259115	GOA
enables metal ion binding	IDA IDA: Inferred from direct assay	29259115	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in protein maturation by [2Fe-2S] cluster transfer	IDA IDA: Inferred from direct assay	29259115	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in mitochondrion	IDA IDA: Inferred from direct assay	17376863	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CISD3 Protein Structure

zf-CDGSH

0
100
127 a.a.

Protein Preferred Names	Protein Names
CDGSH iron-sulfur domain-containing protein 3, mitochondrial	mitoNEET related 2

Related Diseases

Diseases	Alias
Wolfram Syndrome 2	WFS2
Wolfram Syndrome	Didmoad Syndrome Didmoad Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Wfs Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, And Deafness Didmoadud Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Deafness Syndrome Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Hearing Loss Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02725	CISD3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CISD3	RGD	RGD:1559720
Mus musculus	CISD3	MGD	MGI:101788
Bos taurus	CISD3	VGNC	VGNC:27373
Canis familiaris	CISD3	VGNC	VGNC:39280