Smyd2 - SET and MYND domain containing 2 Gene

Also Known as HSKM-B

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 289372

About Smyd2

Primary_assembly 13: 101,425,273-101,466,576 reverse strand.mRatBN7.2:CM026986.1

This gene has 1 transcript (splice variant), 229 orthologues, 5 paralogues and is associated with 3 phenotypes. Biased expression in Muscle (RPKM 828.), Heart (RPKM 47.) and 9 other tissues.

Summary

Predicted to enable RNA polymerase II complex binding activity; Histone Methyltransferase activity (H3-K36 specific); and p53 binding activity. Involved in heart development. Located in cytosol and nucleus. Orthologous to human SMYD2 (SET and MYND domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]

Smyd2 Products (1)

mRNA Protein Name
NM_206851.1 NP_996733.1 N-lysine methyltransferase SMYD2

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in heart development IEP
IEP: Inferred from expression pattern
20305823 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Smyd2 Protein Structure

SET_SMYD2

SET_SMYD2: cd19202 (6 - 268)

zf-MYND

zf-MYND: pfam01753 (51 - 89)

TPR_10

TPR_10: pfam13374 (387 - 421)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 433 a.a.
Protein Preferred Names Protein Names

N-lysine methyltransferase SMYD2

  • SET and MYND domain-containing protein 2

  • histone methyltransferase SMYD2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-19313 LLY-507 Inhibitor 99.09% Unkown
HY-15226 AZ505 Inhibitor 99.99% Unkown
HY-141877 MS4322 Degrader 99.14% Unkown
HY-19546 BAY-598 Inhibitor 99.33% Unkown
HY-15226A AZ505 ditrifluoroacetate Inhibitor 99.89% Unkown
HY-134828 AZ506 Inhibitor 99.74% Unkown
HY-141877B MS4322 (isomer) 99.87% Unkown
HY-19563 A-893 Inhibitor / Unkown
HY-111367 MS2734 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Smyd2 NCBI NCBI:56950