RGCC - regulator of cell cycle Gene

Homo sapiens

Also known as RGC32; RGC-32; C13orf15; bA157L14.2

Gene ID: 28984 | Gene type: protein coding

About RGCC

Cytogenetic location: 13q14.11 Genomic coordinates (GRCh38): 13:41,457,550-41,470,871 (from NCBI)

This gene has 2 transcripts (splice variants) and 194 orthologues. Biased expression in bone marrow (RPKM 99.1), lung (RPKM 65.2) and 11 other tissues.

Summary

This gene is thought to regulate cell cycle progression. It is induced by p53 in response to DNA damage, or by sublytic levels of Complement System proteins that result in activation of the cell cycle. The encoded protein localizes to the cytoplasm during interphase and to centrosomes during mitosis. The protein forms a complex with polo-like kinase 1. The protein also translocates to the nucleus in response to treatment with Complement System proteins, and can associate with and increase the kinase activity of cell division cycle 2 protein. In different assays and cell types, overexpression of this protein has been shown to activate or suppress cell cycle progression. [provided by RefSeq, Jul 2008]

RGCC Products(1)

mRNA	Protein	Name
NM_014059.3	NP_054778.2	regulator of cell cycle RGCC

RGCC Protein Structure

RGCC

0
100
137 a.a.

Protein Preferred Names

Protein Names

regulator of cell cycle RGCC

response gene to complement 32 protein

Related Diseases

Diseases

Alias

Renal Fibrosis

Kahrizi Syndrome

KHRZ	Mental Retardation, Cataract, Coloboma, And Kyphosis, Autosomal Recessive
Intellectual Disability, Kahrizi Type	Intellectual Disability-Cataract-Coloboma-Kyphosis Syndrome

Ischemic Neuropathy

Ischemic Peripheral Neuropathy

Fanconi Anemia, Complementation Group C

Fanconi Anemia Complementation Group C	FANCC
Facc	Fac
Fa3	Fanconi Pancytopenia Type 3
Fanconi Pancytopenia, Type 3	Faces Syndrome
Facial Features , Anorexia, Cachexia, Eye And Skin Anomalies	Friedman-Goodman Syndrome
Abnormality Of The Face

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11889	RGCC Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RGCC	VGNC	VGNC:102307
Rattus norvegicus	RGCC	RGD	RGD:619721
Mus musculus	RGCC	MGD	MGI:1913464
Bos taurus	RGCC	VGNC	VGNC:33902
Macaca mulatta	RGCC	VGNC	VGNC:76783