Chat - choline O-acetyltransferase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 290567

Summary

Enables choline O-acetyltransferase activity and choline binding activity. Involved in several processes, including acetylcholine biosynthetic process; antral ovarian follicle growth; and response to ethanol. Located in neuron projection. Biomarker of Alzheimer's disease and asthma. Human ortholog(s) of this gene implicated in Alzheimer's disease and congenital myasthenic syndrome 6. Orthologous to human CHAT (choline O-acetyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Chat Products (1)

mRNA Protein Name
NM_001170593.1 NP_001164064.1 choline O-acetyltransferase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables choline O-acetyltransferase activity IDA
IDA: Inferred from direct assay
126256 RGD
enables choline binding IDA
IDA: Inferred from direct assay
126256 RGD
Biological Process GO Annotation Evidence References Source
involved in acetylcholine biosynthetic process IDA
IDA: Inferred from direct assay
126256 RGD
involved in antral ovarian follicle growth IEP
IEP: Inferred from expression pattern
16846505 RGD
involved in memory IMP
IMP: Inferred from mutant phenotype
16854393 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
17045751 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
17218023 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
17192613 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
17374747 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

choline O-acetyltransferase

  • CHOACTase

  • choline acetylase

  • choline acetyltransferase

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0764 Bucladesine sodium Activator 99.36% Yes
HY-B0764R Bucladesine sodium (Standard) Activator 99.81% Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-W100403 Choline tosylate Inhibitor 99.90% Phase 4

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N7038 Phytohemagglutinin 80.00% Unkown
HY-N8376 Fustin 99.6% Unkown
HY-N0631 Cornuside Inhibitor 99.99% Unkown
HY-N4119 Neoeriocitrin 99.97% Unkown
HY-159904 ChAT IN-1 Inhibitor 98.51% Unkown
HY-N0801 Polygalacic acid Inhibitor 98.92% Unkown
HY-131574 Heliosupine N-oxide Inhibitor / Unkown
HY-183572 BW813U Inhibitor / Unkown
HY-N4119R Neoeriocitrin (Standard) Inhibitor / Unkown
HY-RS02597 CHAT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12824 SH2D3C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N0631R Cornuside (Standard) Inhibitor / Unkown
HY-RS22115 Chat Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28637 Chat Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Chat NCBI NCBI:1103