Ctsk - cathepsin K Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29175

About Ctsk

Primary_assembly 2: 183,058,569-183,069,550 forward strand.mRatBN7.2:CM026975.1

This gene has 1 transcript (splice variant), 240 orthologues, 27 paralogues and is associated with 16 phenotypes. Biased expression in Uterus (RPKM 264.), Testes (RPKM 141.3) and 9 other tissues.

Summary

Predicted to enable several functions, including Collagen binding activity; fibronectin binding activity; and proteoglycan binding activity. Involved in bone resorption and intramembranous ossification. Located in extracellular space and lysosome. Biomarker of intracranial aneurysm and otitis media. Human ortholog(s) of this gene implicated in pycnodysostosis. Orthologous to human CTSK (Cathepsin K). [provided by Alliance of Genome Resources, Apr 2022]

Ctsk Products (1)

mRNA Protein Name
NM_031560.2 NP_113748.1 cathepsin K precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in bone resorption IMP
IMP: Inferred from mutant phenotype
10430032 RGD
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: Inferred from expression pattern
23110133 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
23110133 RGD
involved in cellular response to zinc ion starvation IEP
IEP: Inferred from expression pattern
21893222 RGD
involved in intramembranous ossification IEP
IEP: Inferred from expression pattern
16193234 RGD
involved in mononuclear cell differentiation IEP
IEP: Inferred from expression pattern
23110133 RGD
involved in proteolysis IDA
IDA: Inferred from direct assay
21893222 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
22576626 RGD
involved in response to insulin IEP
IEP: Inferred from expression pattern
20818503 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
20818503 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
16261450 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ctsk Protein Structure

Inhibitor_I29

Inhibitor_I29: smart00848 (25 - 84)

Peptidase_C1

Peptidase_C1: pfam00112 (114 - 326)

  • 0
  • 100
  • 200
  • 300
  • 329 a.a.
Protein Preferred Names Protein Names

cathepsin K

Recombinant Ctsk Proteins

Cat. No. Product Name Accession Purity
HY-P72158 Cathepsin K Protein, Rat (His) O35186 (V115-M329) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-117200 Necrostatin-7 Inhibitor 99.64% Unkown
HY-143714 Cathepsin K inhibitor 2 Inhibitor / Unkown
HY-155960 SH491 Inhibitor / Unkown
HY-182818 SH494 / Unkown
HY-RS03337 CTSK Human Pre-designed siRNA Set A / Unkown
HY-RS03338 Ctsk Mouse Pre-designed siRNA Set A / Unkown
HY-RS03339 Ctsk Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ctsk NCBI NCBI:1513