Spr - sepiapterin reductase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29270

Summary

Enables sepiapterin reductase activity. Involved in response to organic substance and tetrahydrobiopterin biosynthetic process. Predicted to be located in cytosol and nucleoplasm. Human ortholog(s) of this gene implicated in dystonia and sepiapterin reductase deficiency. Orthologous to human SPR (sepiapterin reductase). [provided by Alliance of Genome Resources, Apr 2022]

Spr Products (1)

mRNA Protein Name
NM_019181.1 NP_062054.1 sepiapterin reductase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables sepiapterin reductase (NADP+) activity IDA
IDA: Inferred from direct assay
2179471 RGD
Biological Process GO Annotation Evidence References Source
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
12604243 RGD
involved in tetrahydrobiopterin biosynthetic process IMP
IMP: Inferred from mutant phenotype
2179471 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sepiapterin reductase

  • sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9905 Cetuximab Inhibitor 99.81% Unkown

Clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Phase
HY-101533 AZD-5991 Inhibitor 99.79% Phase 2
HY-135655 Fobrepodacin disodium Inhibitor 95.27% Phase 2
HY-113603 Tildacerfont Inhibitor 98.60% Phase 2
HY-P1649 SPR741 Inhibitor 99.08% Phase 1
HY-101533B AZD-5991 (S-enantiomer) Inhibitor 99.83% Phase 1
HY-128780 Upleganan Inhibitor / Phase 1
HY-160481 MG-1102 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (56)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13963 ZCL278 Inhibitor 98.49% Unkown
HY-122611A CSRM617 hydrochloride 99.97% Unkown
HY-115510 SPR inhibitor 3 Inhibitor 99.01% Unkown
HY-128780B SPR206 acetate Inhibitor 98.88% Unkown
HY-P1649B SPR741 acetate Inhibitor 99.82% Unkown
HY-114388 QM385 Inducer 99.48% Unkown
HY-135691 hnRNPK-IN-1 97.0% Unkown
HY-101964 SPI-112 Inhibitor 98.01% Unkown
HY-160477 DC-SX029 Inhibitor 98.07% Unkown
HY-12930 SPR719 Inhibitor 99.39% Unkown
HY-159652 KRAS inhibitor-31 Inhibitor 99.36% Unkown
HY-P3143 BMSpep-57 Inhibitor 99.87% Unkown
HY-Y1049 2-Amino-6-bromopyridine Inhibitor 99.97% Unkown
HY-177512 MSC778 Inhibitor / Unkown
HY-W003471 Pyrrolo[2,1-f][1,2,4]triazin-4-amine Inhibitor / Unkown
HY-113603S Tildacerfont-d8 99.97% Unkown
HY-175207 CHI3L1-IN-3 Inhibitor 98.95% Unkown
HY-176537 RGN6024 99.28% Unkown
HY-116992 Chloroneb Inhibitor 96.52% Unkown
HY-101931 hVEGF-IN-1 Inhibitor 99.25% Unkown
HY-P3143A BMSpep-57 hydrochloride Inhibitor 99.69% Unkown
HY-RS13708 SPR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-135655A Fobrepodacin Inhibitor / Unkown
HY-P1649A SPR741 TFA Inhibitor / Unkown
HY-184542 HSF1 ligand-1 Ligand / Unkown
HY-106915 SG-210 Inhibitor / Unkown
HY-122611 CSRM617 / Unkown
HY-128453 LRH-1 antagonist-1 Antagonist / Unkown
HY-13963S ZCL278-13C / Unkown
HY-150506 SPR7 Inhibitor / Unkown
HY-152220 SPR39 Inhibitor / Unkown
HY-152222 SPR38 Inhibitor / Unkown
HY-152224 SPR41 Inhibitor / Unkown
HY-157559 KDRLKZ-2 Ligand / Unkown
HY-161841 Antitumor agent-177 Inhibitor / Unkown
HY-168536 SJ46411 / Unkown
HY-169311 KRAS inhibitor-37 Inhibitor / Unkown
HY-172196 LH168 / Unkown
HY-175142 Prostaglandin E2-PEG11-biotin / Unkown
HY-176732 MJ-26 Inhibitor / Unkown
HY-181530 IAP ligand 6 Ligand / Unkown
HY-181685 LAGi-DEL Inhibitor / Unkown
HY-182049 Antibacterial agent 332 / Unkown
HY-184021 A-8531 Inhibitor / Unkown
HY-184236 Cbl-b-IN-34 Inhibitor / Unkown
HY-187519 KRAS-IN-61 Inhibitor / Unkown
HY-187520 KRAS-IN-62 Inhibitor / Unkown
HY-P3852 Neurokinin Receptor (393-407), rat / Unkown
HY-RS14143 TACR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14144 Tacr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-115569 DC-34 Inhibitor / Unkown
HY-156484 SPR519 Inhibitor / Unkown
HY-168535 SJ6145 / Unkown
HY-181079 RANKL-IN-2 Inhibitor / Unkown
HY-RS16730 Spr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23166 Spr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P9S0008 Cetuximab (PBS) Inhibitor 99.33% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Spr NCBI NCBI:6697