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Cat. No.: HY-152220

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SPR39

SPR39 is a potent SARS-CoV-2 main protease inhibitor with K_i values of 0.252, 3.38, 7.88 µM for SARS-CoV-2 M^pro, hCatL, hCatB, respectively. SPR39 shows antiviral and cytotoxicity.

For research use only. We do not sell to patients.

Formula: C₂₄H₃₁N₃O₅
Molecular Weight:441.52

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

SPR39 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

SPR39 is a potent SARS-CoV-2 main protease inhibitor with K_i values of 0.252, 3.38, 7.88 µM for SARS-CoV-2 M^pro, hCatL, hCatB, respectively. SPR39 shows antiviral and cytotoxicity^[1].

IC₅₀ & Target

K_i: 0.252 µM (SARS-CoV-2 M^pro); 3.38 µM (hCatL); 7.88 µM (hCatB)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
Huh-7	CC₅₀	100 μM Compound: SPR39	Cytotoxicity against human Huh-7 cells overexpressing human ACE2 assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human Huh-7 cells overexpressing human ACE2 assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 36549112]

In Vitro

SPR39 (0-100 µM; 1 h) shows antiviral and cytotoxicity with EC₅₀ of 1.5 µM for SARS-CoV-2 infected Huh-7-ACE2 cells and CC₅₀ of 100 µM for Huh-7-ACE2 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 441.52
Formula C₂₄H₃₁N₃O₅
SMILES

O=C(OCC1=CC=CC=C1)N[C@@H](CC2CC2)C(N[C@H](/C=C/C(C)=O)C[C@H]3C(NCC3)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Previti S, et al. Structure-based lead optimization of peptide-based vinyl methyl ketones as SARS-CoV-2 main protease inhibitors. Eur J Med Chem. 2022 Dec 15;247:115021. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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