2. Anti-infection
  3. Bacterial
  4. Fobrepodacin disodium

Fobrepodacin disodium  (Synonyms: SPR720 disodium; pVXc-486 disodium)

Cat. No.: HY-135655 Purity: 99.53%
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Fobrepodacin (SPR720) disodium is an orally active and potent phosphate proagent of SPR719 (VXc-486; HY-12930). Fobrepodacin disodium has potent bactericidal activities in vivo.

For research use only. We do not sell to patients.

Fobrepodacin disodium Chemical Structure

Fobrepodacin disodium Chemical Structure

CAS No. : 1384984-20-6

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5 mg USD 580 In-stock
10 mg USD 960 In-stock
25 mg USD 1860 In-stock
50 mg USD 2880 In-stock
100 mg USD 4200 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Fobrepodacin disodium:

Fobrepodacin disodium Related Antibodies

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Description

Fobrepodacin (SPR720) disodium is an orally active and potent phosphate proagent of SPR719 (VXc-486; HY-12930). Fobrepodacin disodium has potent bactericidal activities in vivo[1].

In Vivo

Fobrepodacin disodium (oral gavage; 10, 30, 100 mg/kg; once per day; 5 times per week for 4 weeks) reduces the mycobacterial burden in a model of chronic tuberculosis infection in mice[1].
Fobrepodacin disodium (oral; 100 mg/kg; once per day; 5 days per week, for 8 weeks) improves the bactericidal activities of antimycobacterial drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six-week old female BALB/c and C57BL/6 mice uninfected or M. tuberculosis-infected (Erdman)[1]
Dosage: 10, 30, 100 mg/kg
Administration: Oral gavage; once per day; 5 times per week for 4 weeks
Result: Reduced the mycobacterial burden in a model of chronic tuberculosis infection in mice.
Clinical Trial
Molecular Weight

552.40

Formula

C21H24FN6Na2O6P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=NC2=CC(C3=CN=C(C(OP(O[Na])(O[Na])=O)(C)C)N=C3)=C(F)C([C@@H]4OCCC4)=C2N1)NCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (9.05 mM; ultrasonic and adjust pH to 3 with HCl; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8103 mL 9.0514 mL 18.1028 mL
5 mM 0.3621 mL 1.8103 mL 3.6206 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8103 mL 9.0514 mL 18.1028 mL 45.2571 mL
5 mM 0.3621 mL 1.8103 mL 3.6206 mL 9.0514 mL
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Fobrepodacin disodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fobrepodacin disodium1384984-20-6SPR720 disodiumpVXc-486 disodiumBacterialorallyphosphateprodrugVXc-486bactericidalSPR719Inhibitorinhibitorinhibit

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