1. Anti-infection
  2. Bacterial
  3. pVXc-​486

pVXc-​486 

Cat. No.: HY-135655
Handling Instructions

pVXc-486 is an orally active and potent phosphate prodrug of VXc-486. pVXc-486 has potent bactericidal activities in vivo.

For research use only. We do not sell to patients.

pVXc-​486 Chemical Structure

pVXc-​486 Chemical Structure

CAS No. : 1384984-20-6

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Description

pVXc-486 is an orally active and potent phosphate prodrug of VXc-486. pVXc-486 has potent bactericidal activities in vivo[1].

In Vivo

pVXc-486 (oral gavage; 10, 30, 100 mg/kg; once per day; 5 times per week for 4 weeks) reduces the mycobacterial burden in a model of chronic tuberculosis infection in mice[1].
pVXc-486 (oral; 100 mg/kg; once per day; 5 days per week, for 8 weeks) improves the bactericidal activities of antimycobacterial drugs[1].

Animal Model: Six-week old female BALB/c and C57BL/6 mice uninfected or M. tuberculosis-infected (Erdman)[1]
Dosage: 10, 30, 100 mg/kg
Administration: Oral gavage; 5 times per week for 4 weeks
Result: Reduced the mycobacterial burden in a model of chronic tuberculosis infection in mice.
Molecular Weight

552.40

Formula

C₂₁H₂₄FN₆Na₂O₆P

CAS No.

1384984-20-6

SMILES

O=C(NC1=NC2=CC(C3=CN=C(C(OP(O[Na])(O[Na])=O)(C)C)N=C3)=C(F)C([[email protected]@H]4OCCC4)=C2N1)NCC

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

pVXc-​486BacterialorallyphosphateprodrugVXc-486bactericidalInhibitorinhibitorinhibit

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