Fobrepodacin (Synonyms: SPR720; pVXc-486)

Cat. No.: HY-135655A: FAQs
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Fobrepodacin (SPR720) is an orally active and potent phosphate proagent of SPR719 (VXc-486; HY-12930). Fobrepodacin has potent bactericidal activities in vivo.

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Fobrepodacin Chemical Structure

CAS No. : 1384984-31-9

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Other Forms of Fobrepodacin:

Fobrepodacin disodium In-stock

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Description

Fobrepodacin (SPR720) is an orally active and potent phosphate proagent of SPR719 (VXc-486; HY-12930). Fobrepodacin has potent bactericidal activities in vivo^[1].

In Vivo

Fobrepodacin (oral gavage; 10, 30, 100 mg/kg; once per day; 5 times per week for 4 weeks) reduces the mycobacterial burden in a model of chronic tuberculosis infection in mice^[1].
Fobrepodacin (oral; 100 mg/kg; once per day; 5 days per week, for 8 weeks) improves the bactericidal activities of antimycobacterial drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Six-week old female BALB/c and C57BL/6 mice uninfected or M. tuberculosis-infected (Erdman)^[1]
Dosage:	10, 30, 100 mg/kg
Administration:	Oral gavage; once per day; 5 times per week for 4 weeks
Result:	Reduced the mycobacterial burden in a model of chronic tuberculosis infection in mice.

Clinical Trial

Molecular Weight

508.44

Formula

C₂₁H₂₆FN₆O₆P

CAS No.

1384984-31-9

SMILES

O=C(NC1=NC2=CC(C3=CN=C(C(OP(O)(O)=O)(C)C)N=C3)=C(F)C([C@@H]4OCCC4)=C2N1)NCC

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Locher CP, et al. A novel inhibitor of gyrase B is a potent drug candidate for treatment of tuberculosis and nontuberculosis mycobacterial infections.Antimicrob Agents Chemother. 2015 Mar;59(3):1455-65. [Content Brief]

Fobrepodacin Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fobrepodacin1384984-31-9SPR720 pVXc-486SPR 720SPR-720pVXc486pVXc 486pVXc-486BacterialorallyphosphateSPR719VXc-486Inhibitorinhibitorinhibit

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