Tildacerfont-d8
Based on 1 Customer Validation
Tildacerfont-d8 (SPR001-d8; LY2371712-d8) is a deuterium labeled Tildacerfont (HY-113603). Tildacerfont (SPR001; LY2371712) is an orally active, blood-brain barrier-penetrant selective corticotropin-releasing factor type 1 (CRF1) receptor antagonist. Tildacerfont selectively blocks CRF1 receptors, thereby inhibiting the release of pituitary adrenocorticotropic hormone (ACTH). Tildacerfont can be used in research related to congenital adrenal hyperplasia.
For research use only. We do not sell to patients.
- Purity: 99.97%
- CAS No.: 2762751-36-8
- Formula: C20H18D8ClN5OS
- Molecular Weight:428.02
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2762751-36-8
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Unlabeled Cas 1014983-00-6
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Appearance Solid
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Molecular Weight 428.02
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Formula C20H18D8ClN5OS
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Color White to off-white
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SMILES
CC1=NN(C(C(CC)CC)=CC(C)=N2)C2=C1C3=C(Cl)N=C(N4C([2H])([2H])C([2H])([2H])OC([2H])([2H])C4([2H])[2H])S3
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Synonyms
SPR001-d8; LY2371712-d8
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL (233.63 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3363 mL | 11.6817 mL | 23.3634 mL | 58.4085 mL |
| 5 mM | 0.4673 mL | 2.3363 mL | 4.6727 mL | 11.6817 mL | |
| 10 mM | 0.2336 mL | 1.1682 mL | 2.3363 mL | 5.8408 mL | |
| 15 mM | 0.1558 mL | 0.7788 mL | 1.5576 mL | 3.8939 mL | |
| 20 mM | 0.1168 mL | 0.5841 mL | 1.1682 mL | 2.9204 mL | |
| 25 mM | 0.0935 mL | 0.4673 mL | 0.9345 mL | 2.3363 mL | |
| 30 mM | 0.0779 mL | 0.3894 mL | 0.7788 mL | 1.9469 mL | |
| 40 mM | 0.0584 mL | 0.2920 mL | 0.5841 mL | 1.4602 mL | |
| 50 mM | 0.0467 mL | 0.2336 mL | 0.4673 mL | 1.1682 mL | |
| 60 mM | 0.0389 mL | 0.1947 mL | 0.3894 mL | 0.9735 mL | |
| 80 mM | 0.0292 mL | 0.1460 mL | 0.2920 mL | 0.7301 mL | |
| 100 mM | 0.0234 mL | 0.1168 mL | 0.2336 mL | 0.5841 mL |
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