QM385
Based on 3 publication(s) in Google Scholar
QM385 is a potent sepiapterin reductase (SPR) inhibitor with an IC50 of 1.49 nM, which blocks T-cell proliferation and autoimmunity at nanomolar potency and with good oral bioavailability.
For research use only. We do not sell to patients.
- Purity: 99.48%
- CAS No.: 2093421-02-2
- Formula: C17H18F3N7O2
- Molecular Weight:409.37
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) QM385
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Biological Activity
IC50: 1.49 nM (Sepiapterin reductase)[1]
Chemical Information
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CAS No. 2093421-02-2
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Appearance Solid
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Molecular Weight 409.37
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Formula C17H18F3N7O2
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Color Light yellow to yellow
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SMILES
O=C1NC(N2N=CC(C(N3CCN(CC(F)(F)F)CC3)=O)=C2C)=NN4C1=CC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (3)
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Journal Impact Factor
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Most Recent
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Nat Immunol
2026 May;27(5):1026-1038. PMID: 41974963 -
Phytomedicine
Cimifugin suppresses type 2 airway inflammation by binding to SPR and regulating its protein expression in a non-enzymatic manner. [Abstract]2023 Mar:111:154657. PMID: 36701995 -
Solvent & Solubility
DMSO : 125 mg/mL (305.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4428 mL | 12.2139 mL | 24.4278 mL | 61.0694 mL |
| 5 mM | 0.4886 mL | 2.4428 mL | 4.8856 mL | 12.2139 mL | |
| 10 mM | 0.2443 mL | 1.2214 mL | 2.4428 mL | 6.1069 mL | |
| 15 mM | 0.1629 mL | 0.8143 mL | 1.6285 mL | 4.0713 mL | |
| 20 mM | 0.1221 mL | 0.6107 mL | 1.2214 mL | 3.0535 mL | |
| 25 mM | 0.0977 mL | 0.4886 mL | 0.9771 mL | 2.4428 mL | |
| 30 mM | 0.0814 mL | 0.4071 mL | 0.8143 mL | 2.0356 mL | |
| 40 mM | 0.0611 mL | 0.3053 mL | 0.6107 mL | 1.5267 mL | |
| 50 mM | 0.0489 mL | 0.2443 mL | 0.4886 mL | 1.2214 mL | |
| 60 mM | 0.0407 mL | 0.2036 mL | 0.4071 mL | 1.0178 mL | |
| 80 mM | 0.0305 mL | 0.1527 mL | 0.3053 mL | 0.7634 mL | |
| 100 mM | 0.0244 mL | 0.1221 mL | 0.2443 mL | 0.6107 mL |
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