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QM385 

Cat. No.: HY-114388
Handling Instructions

QM385 is a potent sepiapterin reductase (SPR) inhibitor with an IC50 of 1.49 nM, which blocks T-cell proliferation and autoimmunity at nanomolar potency and with good oral bioavailability.

For research use only. We do not sell to patients.

QM385 Chemical Structure

QM385 Chemical Structure

CAS No. : 2296727-52-9

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Description

QM385 is a potent sepiapterin reductase (SPR) inhibitor with an IC50 of 1.49 nM, which blocks T-cell proliferation and autoimmunity at nanomolar potency and with good oral bioavailability[1].

IC50 & Target

IC50: 1.49 nM (Sepiapterin reductase)[1]

In Vitro

QM385 effectively inhibits the proliferation of human CD4+ T cells at low doses[1].

Molecular Weight

408.38

Formula

C₁₈H₁₉F₃N₆O₂

CAS No.

2296727-52-9

SMILES

O=C1NC(N2N=CC(C(N3CCC(CC(F)(F)F)CC3)=O)=C2C)=NN4C1=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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QM385
Cat. No.:
HY-114388
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