Bag3 - BAG cochaperone 3 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 293524

Summary

Predicted to enable adenyl-nucleotide exchange factor activity and chaperone binding activity. Involved in several processes, including central nervous system development; chaperone-mediated autophagy; and negative regulation of protein targeting to mitochondrion. Located in neuron projection and stress fiber. Used to study glioblastoma. Biomarker of visual epilepsy. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1HH and myofibrillar myopathy 6. Orthologous to human BAG3 (BAG cochaperone 3). [provided by Alliance of Genome Resources, Apr 2022]

Bag3 Products (1)

mRNA Protein Name
NM_001011936.1 NP_001011936.1 BAG family molecular chaperone regulator 3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
21561597 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
21561597 RGD
involved in negative regulation of protein targeting to mitochondrion IMP
IMP: Inferred from mutant phenotype
21561597 RGD
involved in spinal cord development IEP
IEP: Inferred from expression pattern
19415333 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

BAG family molecular chaperone regulator 3

  • Bcl2-associated athanogene 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-117282 JG-98 99.88% Unkown
HY-156278 FB49 Inhibitor 99.76% Unkown
HY-170944 BAG3/HSP70-IN-1 / Unkown
HY-180948 PZ-11 Inducer / Unkown
HY-RS01344 BAG3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17327 Bag3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23782 Bag3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992379 IB001 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bag3 NCBI NCBI:9531