S1pr2 - sphingosine-1-phosphate receptor 2 Gene

Also Known as Edg5; H218; GPCR18; Gpcr13; snGPCR18

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29415

About S1pr2

Primary_assembly 8: 19,502,627-19,523,574 reverse strand.mRatBN7.2:CM026981.1

This gene has 2 transcripts (splice variants), 192 orthologues, 18 paralogues and is associated with 6 phenotypes. Biased expression in Lung (RPKM 99.8), Heart (RPKM 92.4) and 9 other tissues.

Summary

Enables G protein-coupled peptide receptor activity. Acts upstream of or within G protein-coupled receptor signaling pathway; negative regulation of smooth muscle cell migration; and negative regulation of vascular associated smooth muscle cell proliferation. Predicted to be integral component of membrane. Predicted to be active in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 68. Orthologous to human S1PR2 (sphingosine-1-phosphate receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

S1pr2 Products (1)

mRNA Protein Name
NM_017192.2 NP_058888.1 sphingosine 1-phosphate receptor 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled peptide receptor activity IDA
IDA: Inferred from direct assay
29453251 RGD
enables G protein-coupled receptor activity IDA
IDA: Inferred from direct assay
9409733 RGD
Biological Process GO Annotation Evidence References Source
acts upstream of or within G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
29453251 RGD
acts upstream of or within negative regulation of smooth muscle cell migration IGI
IGI: Inferred from genetic interaction
29453251 RGD
acts upstream of or within negative regulation of vascular associated smooth muscle cell proliferation IGI
IGI: Inferred from genetic interaction
29453251 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

S1pr2 Protein Structure

7tmA_S1PR2_Edg5

7tmA_S1PR2_Edg5: cd15347 (34 - 298)

7tmA_S1PR2_Edg5

7tmA_S1PR2_Edg5: cd15347 (34 - 60)

7tmA_S1PR2_Edg5

7tmA_S1PR2_Edg5: cd15347 (67 - 92)

7tmA_S1PR2_Edg5

7tmA_S1PR2_Edg5: cd15347 (104 - 134)

7tmA_S1PR2_Edg5

7tmA_S1PR2_Edg5: cd15347 (145 - 165)

7tmA_S1PR2_Edg5

7tmA_S1PR2_Edg5: cd15347 (185 - 214)

7tmA_S1PR2_Edg5

7tmA_S1PR2_Edg5: cd15347 (225 - 255)

7tmA_S1PR2_Edg5

7tmA_S1PR2_Edg5: cd15347 (266 - 291)

  • 0
  • 100
  • 200
  • 300
  • 352 a.a.
Protein Preferred Names Protein Names

sphingosine 1-phosphate receptor 2

  • AGR16

  • G-protein coupled receptor 13

  • G-protein coupled receptor H218

  • S1P receptor 2

  • S1P receptor Edg-5

  • S1P2

  • endothelial differentiation G-protein coupled receptor 5

  • endothelial differentiation, sphingolipid G-protein-coupled receptor, 5

  • sphingosine 1-phosphate receptor Edg-5

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12355 Siponimod Agonist 99.95% Yes
HY-12355A Siponimod hemifumarate Agonist 99.64% Yes

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-111253 CYM-5478 Agonist 99.90% Unkown
HY-139310 GLPG2938 Antagonist 99.94% Unkown
HY-176533 S1PR5-IN-1 Inhibitor 99.58% Unkown
HY-N1423B Glycocholic acid hydrate Activator 99.85% Unkown
HY-113934 L-threo Lysosphingomyelin (d18:1) Agonist 98.0% Unkown
HY-120409 AB1 Inhibitor / Unkown
HY-182618 XAX-162 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens S1pr2 NCBI NCBI:9294