Rgs4 - regulator of G-protein signaling 4 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29480

About Rgs4

Primary_assembly 13: 81,936,775-81,943,068 reverse strand.mRatBN7.2:CM026986.1

This gene has 3 transcripts (splice variants), 197 orthologues, 22 paralogues and is associated with 13 phenotypes. Biased expression in Brain (RPKM 76.9), Adrenal (RPKM 271.2) and 4 other tissues.

Summary

Enables G-protein alpha-subunit binding activity and GTPase activator activity. Involved in several processes, including regulation of ion transport; regulation of signal transduction; and response to alkaloid. Located in cytosol; nucleus; and plasma membrane. Part of protein-containing complex. Used to study epilepsy. Biomarker of bladder disease; hypertension; lesion of sciatic nerve; opioid abuse; and status epilepticus. Orthologous to human RGS4 (regulator of G protein signaling 4). [provided by Alliance of Genome Resources, Apr 2022]

Rgs4 Products (1)

mRNA Protein Name
NM_017214.2 NP_058910.1 regulator of G-protein signaling 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G-protein alpha-subunit binding IDA
IDA: Inferred from direct assay
9108480 RGD
enables G-protein alpha-subunit binding IPI
IPI: Inferred from physical interaction
20530129 RGD
enables GTPase activator activity IDA
IDA: Inferred from direct assay
10942773 RGD
enables GTPase activator activity IMP
IMP: Inferred from mutant phenotype
9430692 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
17084383 RGD
Biological Process GO Annotation Evidence References Source
involved in dorsal root ganglion development IEP
IEP: Inferred from expression pattern
14550772 RGD
involved in negative regulation of G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
9918533 RGD
involved in negative regulation of cell growth involved in cardiac muscle cell development IDA
IDA: Inferred from direct assay
9918533 RGD
involved in negative regulation of dopamine receptor signaling pathway IDA
IDA: Inferred from direct assay
21896332 RGD
involved in negative regulation of glycine import across plasma membrane IMP
IMP: Inferred from mutant phenotype
21798518 RGD
involved in negative regulation of potassium ion transmembrane transport IDA
IDA: Inferred from direct assay
24421355 RGD
involved in positive regulation of GTPase activity IMP
IMP: Inferred from mutant phenotype
9430692 RGD
involved in positive regulation of excitatory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
17220354 RGD
involved in positive regulation of heart rate IMP
IMP: Inferred from mutant phenotype
25844489 RGD
involved in regulation of actin filament organization IDA
IDA: Inferred from direct assay
9918533 RGD
involved in regulation of calcium ion transport IDA
IDA: Inferred from direct assay
16699510 RGD
involved in regulation of potassium ion transmembrane transport IDA
IDA: Inferred from direct assay
11906535 RGD
involved in response to amphetamine IEP
IEP: Inferred from expression pattern
26321241 RGD
involved in response to cocaine IEP
IEP: Inferred from expression pattern
17632279 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
28736108 RGD
Cellular Component GO Annotation Evidence References Source
part of protein-containing complex IDA
IDA: Inferred from direct assay
9108480 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Rgs4 Protein Structure

RGS_RGS4

RGS_RGS4: cd08714 (62 - 175)

  • 0
  • 100
  • 205 a.a.
Protein Preferred Names Protein Names

regulator of G-protein signaling 4

  • RGP4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13509 CCG-50014 Inhibitor 99.62% Unkown
HY-U00431 CCG 203769 Inhibitor 99.76% Unkown
HY-70074 CCG-63802 Inhibitor 98.83% Unkown
HY-70075 CCG-63808 Inhibitor 98.0% Unkown
HY-110054 CCG-2046 Inhibitor / Unkown
HY-122251 CCG-4986 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rgs4 NCBI NCBI:5999