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RGS4 - regulator of G protein signaling 4 Gene

Also Known as RGP4; SCZD9

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5999

About RGS4

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:163,068,871-163,076,802 (from NCBI)

This gene has 10 transcripts (splice variants), 197 orthologues and 23 paralogues. Biased expression in brain (RPKM 67.5), adrenal (RPKM 15.7) and 1 other tissue.

Summary

Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat RGS4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

RGS4 Products (4)

mRNA	Protein	Name
NM_005613.6	NP_005604.1	regulator of G-protein signaling 4 isoform 2
NM_001102445.3	NP_001095915.1	regulator of G-protein signaling 4 isoform 1
NM_001113381.1	NP_001106852.1	regulator of G-protein signaling 4 isoform 4
NM_001113380.1	NP_001106851.1	regulator of G-protein signaling 4 isoform 3

Gene Ontology

Cellular Component

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10791963	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10791963	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RGS4 Protein Structure

RGS

0
100
205 a.a.

Protein Preferred Names	Protein Names
regulator of G-protein signaling 4	schizophrenia disorder 9

Related Diseases

Diseases	Alias
Johanson-Blizzard Syndrome	JBS Nasal Alar Hypoplasia, Hypothyroidism, Pancreatic Achylia, And Congenital Deafness Nasal Alar Hypoplasia, Hypothyroidism, Pancreatic Achylia And Congenital Deafness Johanson Blizzard Syndrome
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Psychotic Disorder	Psychotic Disorders Mental Or Behavioural Disorder Psychotic Mental Disorders
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Schizophreniform Disorder	Schizophreniform Disorders Psychotic Disorders
Schizoaffective Disorder	Schizo-Affective Psychosis Schizo-Affective Type Schizophrenia Schizoaffective Psychosis Schizoaffective Schizophrenia Schizophrenia, Schizo-Affective Type Schizophreniform Psychosis, Affective Type

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13509	CCG-50014	Inhibitor	99.62%	Unkown
HY-U00431	CCG 203769	Inhibitor	99.76%	Unkown
HY-70074	CCG-63802	Inhibitor	98.83%	Unkown
HY-70075	CCG-63808	Inhibitor	98.0%	Unkown
HY-110054	CCG-2046	Inhibitor	/	Unkown
HY-122251	CCG-4986	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RGS4	VGNC	VGNC:76690
Felis catus	RGS4	VGNC	VGNC:64596
Rattus norvegicus	RGS4	RGD	RGD:3567
Canis familiaris	RGS4	VGNC	VGNC:45534
Bos taurus	RGS4	VGNC	VGNC:54394
Mus musculus	RGS4	MGD	MGI:108409
Others	RGS4	NCBI