2. GPCR/G Protein
  3. RGS Protein
  4. CCG-63802

CCG-63802 is a selective, reversible and allosteric RGS4 inhibitor. CCG-63802 specifically binds to RGS4 and blocks the RGS4-Gαo interaction, with an IC50 value of 1.9 μM.

For research use only. We do not sell to patients.

CCG-63802 Chemical Structure

CCG-63802 Chemical Structure

CAS No. : 620112-78-9

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Customer Review

Based on 2 publication(s) in Google Scholar

CCG-63802 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE CCG-63802

WB

    CCG-63802 purchased from MedChemExpress. Usage Cited in: Inflammation. 2018 Dec;41(6):2079-2089.  [Abstract]

    The expression levels of EKR, Akt/mTOR, and TIMP proteins in OVA-induced asthma are measured and quantified by Western blot.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    CCG-63802 is a selective, reversible and allosteric RGS4 inhibitor. CCG-63802 specifically binds to RGS4 and blocks the RGS4-Gαo interaction, with an IC50 value of 1.9 μM[1].

    IC50 & Target[1]

    RGS4

    1.9 μM (IC50)

    In Vitro

    CCG-63802 (5 μM) inhibits regulators of G-protein signaling (RGS) proteins in the presence of BK (bradykinin) and 8-Br-cGMP (membrane-permeable analogue of cGMP), HEK-293 cells start to depolarize again[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    CCG-63802 Related Antibodies
    In Vivo

    CCG-63802 (0.05 mg/kg; intratracheal administration; once per week; 90 days) reduces RGS4 protein expression, leading to partially abrogate the attenuating effect of PGZ on airway inflammation, hyperresponsiveness (AHR), and remodeling[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Forty female BALB/c mice aged 6-8 week old[3]
    Dosage: 0.05 mg/kg
    Administration: Intratracheal administration; once per week; 90 days
    Result: CCG 63802 treatment in OVA +PGZ + CCG group significantly reduced RGS4 protein expression compared to OVA + PGZ group (P < 0.05)
    Molecular Weight

    450.51

    Formula

    C26H18N4O2S
    CAS No.
    Appearance

    Solid

    Color

    Yellow to orange

    SMILES

    N#C/C(C1=NC2=CC=CC=C2S1)=C\C3=C(N=C4C(C)=CC=CN4C3=O)OC5=CC=CC(C)=C5
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    DMSO : 1.67 mg/mL (3.71 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.2197 mL 11.0985 mL 22.1971 mL
    5 mM --- --- ---
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    C2

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    Volume (final)

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    In Vivo:

    The following protocol is derived from the literature and is for reference only. It is recommended to first try a small sample.

    • Protocol 1

      CCG-63802 is dissolved in DMSO and diluted with 0.9% NaCl[3].

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

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    (per animal)

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 99.26%

    COA (257 KB) RP-HPLC (243 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.2197 mL 11.0985 mL 22.1971 mL 55.4927 mL
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    CCG-63802 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    CCG-63802620112-78-9CCG63802CCG 63802RGS ProteinRegulators of G-protein SignalingRegulator of G-protein SignalingselectivereversibleRGSinflammationInhibitorinhibitorinhibit

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    Product Name:
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    Cat. No.:
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