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Ptgs2 - prostaglandin-endoperoxide synthase 2 Gene

Also Known as Cox2; COX-2; PGHS-2; PHS II

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 29527

Summary

Enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. Involved in several processes, including learning or memory; modulation of chemical synaptic transmission; and positive regulation of cytokine production. Acts upstream of or within bone mineralization. Located in cytoplasm. Part of protein-containing complex. Colocalizes with caveola. Used to study several diseases, including Barrett's esophagus; brain disease (multiple); hypertension (multiple); lung disease (multiple); and neurodegenerative disease (multiple). Biomarker of several diseases, including carcinoma (multiple); glioblastoma (multiple); inflammatory bowel disease (multiple); pleurisy; and visual epilepsy. Human ortholog(s) of this gene implicated in several diseases, including arthritis (multiple); avian influenza; cardiovascular system disease (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human PTGS2 (prostaglandin-endoperoxide synthase 2). [provided by Alliance of Genome Resources, Apr 2022]

Ptgs2 Products (1)

mRNA	Protein	Name
NM_017232.4	NP_058928.3	prostaglandin G/H synthase 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IDA IDA: Inferred from direct assay	8203528	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16479074	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in angiogenesis	IMP IMP: Inferred from mutant phenotype	21273371	RGD
acts upstream of or within bone mineralization	IMP IMP: Inferred from mutant phenotype	18519738	RGD
involved in cellular response to ATP	IEP IEP: Inferred from expression pattern	21678415	RGD
involved in cellular response to heat	IEP IEP: Inferred from expression pattern	22777528	RGD
involved in cellular response to homocysteine	IEP IEP: Inferred from expression pattern	31125437	RGD
involved in cellular response to lead ion	IEP IEP: Inferred from expression pattern	25193092	RGD
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	18769055	RGD
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	21051526	RGD
involved in decidualization	IMP IMP: Inferred from mutant phenotype	17485303	RGD
involved in embryo implantation	IMP IMP: Inferred from mutant phenotype	17485303	RGD
involved in hair cycle	IEP IEP: Inferred from expression pattern	19180200	RGD
involved in learning	IMP IMP: Inferred from mutant phenotype	21701788	RGD
involved in maintenance of blood-brain barrier	IMP IMP: Inferred from mutant phenotype	17704356	RGD
involved in memory	IMP IMP: Inferred from mutant phenotype	18540883	RGD
involved in negative regulation of calcium ion transport	IMP IMP: Inferred from mutant phenotype	17766482	RGD
involved in negative regulation of cell cycle	IGI IGI: Inferred from genetic interaction	11756433	RGD
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	11756433	RGD
involved in negative regulation of smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	21051526	RGD
involved in negative regulation of synaptic transmission, dopaminergic	IMP IMP: Inferred from mutant phenotype	18764909	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	17828456	RGD
involved in positive regulation of cell migration involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	9630216	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	22165968	RGD
involved in positive regulation of fever generation	IDA IDA: Inferred from direct assay	19940926	RGD
involved in positive regulation of fibroblast growth factor production	IMP IMP: Inferred from mutant phenotype	9630216	RGD
involved in positive regulation of nitric oxide biosynthetic process	IMP IMP: Inferred from mutant phenotype	9630216	RGD
involved in positive regulation of platelet-derived growth factor production	IMP IMP: Inferred from mutant phenotype	9630216	RGD
involved in positive regulation of protein import into nucleus	IMP IMP: Inferred from mutant phenotype	20472710	RGD
involved in positive regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	17645304	RGD
involved in positive regulation of smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	18480553	RGD
involved in positive regulation of synaptic plasticity	IMP IMP: Inferred from mutant phenotype	18540883	RGD
involved in positive regulation of synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	18764909	RGD
involved in positive regulation of transforming growth factor beta production	IMP IMP: Inferred from mutant phenotype	9630216	RGD
involved in positive regulation of vascular endothelial growth factor production	IMP IMP: Inferred from mutant phenotype	9630216	RGD
involved in positive regulation of vasoconstriction	IMP IMP: Inferred from mutant phenotype	17245358	RGD
involved in prostaglandin biosynthetic process	IMP IMP: Inferred from mutant phenotype	17673564	RGD
involved in response to angiotensin	IEP IEP: Inferred from expression pattern	21311042	RGD
involved in response to cytokine	IMP IMP: Inferred from mutant phenotype	18383135	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	18310519	RGD
involved in response to fatty acid	IEP IEP: Inferred from expression pattern	16983392	RGD
involved in response to fructose	IEP IEP: Inferred from expression pattern	17883899	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	18657281	RGD
involved in response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	17766482	RGD
involved in response to manganese ion	IEP IEP: Inferred from expression pattern	17827730	RGD
involved in response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	17704356	RGD
involved in response to vitamin D	IEP IEP: Inferred from expression pattern	18348265	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	17883899	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in caveola	IDA IDA: Inferred from direct assay	16479074	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	20950588	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	16479074	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
prostaglandin G/H synthase 2	PGH synthase 2 cyclooxygenase-2 prostaglandin H2 synthase 2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-163897	PROTAC NCOA4 degrader-1	Inhibitor	99.75%	Unkown
HY-N6929	Angelic acid		99.20%	Unkown
HY-RS11393	PTGS2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-121025	BUR1	Inhibitor	99.65%	Unkown
HY-175813	NPSR1 antagonist-1		/	Unkown
HY-N16797	Sanggenol C		/	Unkown
HY-N17632	Moracin G		/	Unkown
HY-N18209	4-Hydroxy-3-butylphthalide		/	Unkown
HY-N19877	Neokadsuranic acid B		/	Unkown
HY-N20647	Jioglutolide	Inhibitor	/	Unkown
HY-RS16902	Ptgs2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23344	Ptgs2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ptgs2	NCBI	NCBI:5743