Aldh2 - aldehyde dehydrogenase 2 family member Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29539

About Aldh2

Primary_assembly 12: 34,901,219-34,982,521 forward strand.mRatBN7.2:CM026985.1

This gene has 7 transcripts (splice variants), 224 orthologues and 20 paralogues. Biased expression in Liver (RPKM 1581.), Adrenal (RPKM 143.4) and 9 other tissues.

Summary

Enables NADH binding activity; aldehyde dehydrogenase (NAD+) activity; and identical protein binding activity. Involved in several processes, including behavioral response to ethanol; cellular response to resveratrol; and response to ischemia. Located in mitochondrial matrix. Biomarker of heart disease. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; artery disease (multiple); diabetes mellitus (multiple); diabetic neuropathy; and liver disease (multiple). Orthologous to human ALDH2 (aldehyde dehydrogenase 2 family member). [provided by Alliance of Genome Resources, Apr 2022]

Aldh2 Products (1)

mRNA Protein Name
NM_032416.2 NP_115792.2 aldehyde dehydrogenase, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables NADH binding IDA
IDA: Inferred from direct assay
21276780 RGD
enables aldehyde dehydrogenase (NAD+) activity IDA
IDA: Inferred from direct assay
4149764 RGD
enables aldehyde dehydrogenase (NAD+) activity IMP
IMP: Inferred from mutant phenotype
18787169 RGD
enables identical protein binding IDA
IDA: Inferred from direct assay
1898068 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
23403928 RGD
Biological Process GO Annotation Evidence References Source
involved in acetaldehyde metabolic process IMP
IMP: Inferred from mutant phenotype
11535626 RGD
involved in apoptotic mitochondrial changes IEP
IEP: Inferred from expression pattern
30131474 RGD
involved in behavioral response to ethanol IMP
IMP: Inferred from mutant phenotype
11535626 RGD
involved in cellular detoxification of aldehyde IMP
IMP: Inferred from mutant phenotype
29589772 RGD
involved in cellular response to fatty acid IEP
IEP: Inferred from expression pattern
11463352 RGD
involved in cellular response to hormone stimulus IEP
IEP: Inferred from expression pattern
8749803 RGD
involved in cellular response to resveratrol IEP
IEP: Inferred from expression pattern
28688179 RGD
involved in ethanol metabolic process IEP
IEP: Inferred from expression pattern
28688179 RGD
involved in intrinsic apoptotic signaling pathway in response to oxidative stress IMP
IMP: Inferred from mutant phenotype
29589772 RGD
involved in liver development IEP
IEP: Inferred from expression pattern
16291827 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
21123025 RGD
involved in regulation of reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
29589772 RGD
involved in regulation of response to oxidative stress IEP
IEP: Inferred from expression pattern
30131474 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
16339744 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
28688179 RGD
involved in response to hyperoxia IEP
IEP: Inferred from expression pattern
16782756 RGD
involved in response to ischemia IEP
IEP: Inferred from expression pattern
30131474 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
11578593 RGD
involved in response to nicotine IEP
IEP: Inferred from expression pattern
12359213 RGD
involved in response to organic cyclic compound IMP
IMP: Inferred from mutant phenotype
29589772 RGD
involved in response to progesterone IEP
IEP: Inferred from expression pattern
8749803 RGD
involved in response to testosterone IEP
IEP: Inferred from expression pattern
8749803 RGD
Cellular Component GO Annotation Evidence References Source
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
29491208 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Aldh2 Protein Structure

ALDH_F1AB_F2_RALDH1

ALDH_F1AB_F2_RALDH1: cd07141 (32 - 512)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 519 a.a.
Protein Preferred Names Protein Names

aldehyde dehydrogenase, mitochondrial

  • ALDH class 2

  • ALDH-E2

  • ALDH1

  • aldehyde dehydrogenase 2 family (mitochondrial)

  • aldehyde dehydrogenase 2, mitochondrial

  • mitochondrial aldehyde dehydrogenase

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0364A Dyclonine hydrochloride Inhibitor 99.12% Unkown

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-113466 4-Hydroxynonenal Inhibitor 99.75% Unkown
HY-18936 Alda-1 Agonist 99.99% Unkown
HY-19801 CVT-10216 Inhibitor 99.87% Unkown
HY-76006 3-Hydroxybenzaldehyde 99.93% Unkown
HY-146683 KS106 Inhibitor 99.87% Unkown
HY-113466S 4-Hydroxynonenal-d3 Inhibitor 99.0% Unkown
HY-176716 ALDH2 activator 1 Agonist 98.88% Unkown
HY-126241 RV01 Inhibitor 98.06% Unkown
HY-B0364AS Dyclonine-d9 hydrochloride Inhibitor / Unkown
HY-148617 ALDH2 modulator 1 Modulator / Unkown
HY-182636 MT16-001 / Unkown
HY-160475 AD-9308 Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aldh2 NCBI NCBI:217