CASK - Cask calcium/calmodulin dependent serine protein kinase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29647

Summary

Enables PDZ domain binding activity; neurexin family protein binding activity; and protein C-terminus binding activity. Involved in several processes, including nervous system development; positive regulation of Insulin secretion; and protein localization to plasma membrane. Located in several cellular components, including apical dendrite; basolateral plasma membrane; and podocyte foot. Part of protein-containing complex. Human ortholog(s) of this gene implicated in FG syndrome and syndromic X-linked intellectual disability Najm type. Orthologous to human CASK (calcium/Calmodulin dependent serine protein kinase). [provided by Alliance of Genome Resources, Apr 2022]

CASK Products (1)

mRNA Protein Name
NM_022184.1 NP_071520.1 peripheral plasma membrane protein CASK

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables PDZ domain binding IPI
IPI: Inferred from physical interaction
9660869 RGD
enables neurexin family protein binding IPI
IPI: Inferred from physical interaction
8786425 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9660869 RGD
enables protein kinase C binding IPI
IPI: Inferred from physical interaction
17084383 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
15331416 RGD
Biological Process GO Annotation Evidence References Source
involved in cerebral cortex development IEP
IEP: Inferred from expression pattern
10749215 RGD
involved in positive regulation of dendritic spine morphogenesis IMP
IMP: Inferred from mutant phenotype
18606847 RGD
involved in positive regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
24140090 RGD
involved in protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
14960569 RGD
involved in regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19275891 RGD
Cellular Component GO Annotation Evidence References Source
located in apical dendrite IDA
IDA: Inferred from direct assay
9660869 RGD
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
10710551 RGD
located in ciliary membrane IDA
IDA: Inferred from direct assay
18596612 RGD
located in dendrite IDA
IDA: Inferred from direct assay
12641734 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
9660869 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
9660869 RGD
located in nucleus IDA
IDA: Inferred from direct assay
18664494 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
12641734 RGD
located in podocyte foot IDA
IDA: Inferred from direct assay
15994232 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
9660869 RGD
is active in postsynaptic density, intracellular component IDA
IDA: Inferred from direct assay
24753440 RGD
is active in presynapse IDA
IDA: Inferred from direct assay
9660869 RGD
located in presynaptic membrane IDA
IDA: Inferred from direct assay
18596612 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
11356864 RGD
located in synaptic membrane IDA
IDA: Inferred from direct assay
8786425 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

peripheral plasma membrane protein CASK

  • calcium/calmodulin-dependent serine protein kinase (MAGUK family)

  • peripheral plasma membrane protein CASK-like

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-115719 NR162 Inhibitor 99.7% Unkown
HY-RS01938 CASK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18466 Cask Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24947 Cask Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens CASK NCBI NCBI:8573