Pde1b - phosphodiesterase 1B Gene

Also Known as Aop2; Pde1b1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29691

Summary

Enables cyclic-nucleotide phosphodiesterase activity. Predicted to be involved in cellular response to cytokine stimulus; monocyte differentiation; and signal transduction. Predicted to act upstream of or within several processes, including response to amphetamine; serotonin metabolic process; and visual learning. Located in neuronal cell body. Biomarker of Parkinsonism. Orthologous to human PDE1B (phosphodiesterase 1B). [provided by Alliance of Genome Resources, Apr 2022]

Pde1b Products (1)

mRNA Protein Name
NM_022710.1 NP_073201.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
IDA: Inferred from direct assay
1326532 RGD
enables cyclic-nucleotide phosphodiesterase activity IDA
IDA: Inferred from direct assay
1326532 RGD
Cellular Component GO Annotation Evidence References Source
located in neuronal cell body IDA
IDA: Inferred from direct assay
15305867 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B

calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B

  • 63 kDa Cam-PDE

  • anti-oxidant protein 2

  • cam-PDE 1B

  • cyclic nucleotide phosphodiesterase (CaM-PDE)

  • phosphodiesterase 1B, Ca2+calmodulin dependent

  • phosphodiesterase 1B, calmodulin-dependent

  • phosphodiesterase 1B1, Ca2+-calmodulin dependent, 63 kDa

  • phosph

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-12501A ITI-214 Inhibitor 99.56% Phase 2

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-136569 DSR-141562 Inhibitor 99.98% Unkown
HY-101490 PDE1-IN-2 Inhibitor 98.0% Unkown
HY-12501 ITI-214 free base Inhibitor 98.0% Unkown
HY-120741 PF-04822163 Inhibitor / Unkown
HY-120195 PF-04677490 Inhibitor / Unkown
HY-120195A PF-04827736 Inhibitor / Unkown
HY-147946 PDE1-IN-4 Inhibitor / Unkown
HY-180803 LH17 Inhibitor / Unkown
HY-RS10211 PDE1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17837 Pde1b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24305 Pde1b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pde1b NCBI NCBI:5153