Gclm - glutamate cysteine ligase, modifier subunit Gene

Also Known as Glclr

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29739

Summary

Enables glutamate-cysteine Ligase activity and glutamate-cysteine Ligase catalytic subunit binding activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to thyroxine stimulus; and response to gonadotropin. Part of glutamate-cysteine Ligase complex. Human ortholog(s) of this gene implicated in myocardial infarction and vascular dementia. Orthologous to human GCLM (glutamate-cysteine Ligase modifier subunit). [provided by Alliance of Genome Resources, Apr 2022]

Gclm Products (1)

mRNA Protein Name
NM_017305.2 NP_059001.1 glutamate--cysteine ligase regulatory subunit

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glutamate-cysteine ligase activity IDA
IDA: Inferred from direct assay
8104188 RGD
contributes to glutamate-cysteine ligase activity IMP
IMP: Inferred from mutant phenotype
16183645 RGD
enables glutamate-cysteine ligase catalytic subunit binding IDA
IDA: Inferred from direct assay
16137247 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
16137247 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to fibroblast growth factor stimulus IEP
IEP: Inferred from expression pattern
18042181 RGD
involved in cellular response to follicle-stimulating hormone stimulus IEP
IEP: Inferred from expression pattern
18042181 RGD
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
20466058 RGD
involved in cellular response to hepatocyte growth factor stimulus IEP
IEP: Inferred from expression pattern
20466058 RGD
involved in cellular response to thyroxine stimulus IEP
IEP: Inferred from expression pattern
17291985 RGD
involved in glutathione biosynthetic process IMP
IMP: Inferred from mutant phenotype
16183645 RGD
involved in hepatic stellate cell activation IEP
IEP: Inferred from expression pattern
22942279 RGD
involved in negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
16183645 RGD
involved in positive regulation of glutamate-cysteine ligase activity IDA
IDA: Inferred from direct assay
16137247 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
20018823 RGD
involved in response to human chorionic gonadotropin IEP
IEP: Inferred from expression pattern
15811874 RGD
involved in response to nitrosative stress IMP
IMP: Inferred from mutant phenotype
16183645 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
22906634 RGD
involved in response to oxidative stress IMP
IMP: Inferred from mutant phenotype
16183645 RGD
Cellular Component GO Annotation Evidence References Source
part of glutamate-cysteine ligase complex IDA
IDA: Inferred from direct assay
16137247 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glutamate--cysteine ligase regulatory subunit

  • GCS light chain

  • gamma-ECS regulatory subunit

  • gamma-glutamylcysteine synthetase regulatory subunit

  • glutamate cysteine ligase (gamma-glutamylcysteine synthetase), regulatory

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W015600 2-Acetamidophenol 99.73% Unkown
HY-171705 KMS99220 99.48% Unkown
HY-147517 Keap1-Nrf2-IN-9 Inhibitor 98.52% Unkown
HY-121523 MIND4-17 Activator 99.05% Unkown
HY-W015600S 2-Acetamidophenol-d3 99.48% Unkown
HY-172598 SG16 Inhibitor / Unkown
HY-181907 NBE5 / Unkown
HY-RS05334 GCLM Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18936 Gclm Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25426 Gclm Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gclm NCBI NCBI:2730