Tlr1 - toll-like receptor 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 305354

About Tlr1

Primary_assembly 14: 43,384,932-43,397,125 forward strand.mRatBN7.2:CM026987.1

This gene has 3 transcripts (splice variants), 73 orthologues, 26 paralogues and is associated with 14 phenotypes. Biased expression in Spleen (RPKM 82.1), Kidney (RPKM 4.5) and 8 other tissues.

Summary

Enables Lipopeptide binding activity. Involved in microglial cell activation; response to Bacterial lipoprotein; and Toll-like Receptor signaling pathway. Predicted to be located in Golgi apparatus and membrane raft. Predicted to be part of Toll-like Receptor 1-Toll-like receptor 2 protein complex. Biomarker of perinatal necrotizing enterocolitis. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; aspergillosis; leprosy; pyelonephritis; and tuberculosis. Orthologous to human TLR1 (toll like receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Tlr1 Products (1)

mRNA Protein Name
NM_001172120.2 NP_001165591.1 toll-like receptor 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables lipopeptide binding IDA
IDA: Inferred from direct assay
16973131 RGD
Biological Process GO Annotation Evidence References Source
involved in microglial cell activation IDA
IDA: Inferred from direct assay
16973131 RGD
involved in response to bacterial lipoprotein IDA
IDA: Inferred from direct assay
16973131 RGD
involved in toll-like receptor signaling pathway IDA
IDA: Inferred from direct assay
16973131 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tlr1 Protein Structure

PRK15370

PRK15370: cl33128 (50 - 145)

LRR_1

LRR_1: sd00031 (62 - 85)

LRR_1

LRR_1: sd00031 (86 - 109)

LRR_1

LRR_1: sd00031 (110 - 124)

LRR_1

LRR_1: sd00031 (131 - 155)

LRR_1

LRR_1: sd00031 (156 - 168)

PRK15370

PRK15370: cl33128 (312 - 499)

LRR_RI

LRR_RI: sd00033 (367 - 388)

LRR_RI

LRR_RI: sd00033 (389 - 414)

LRR_RI

LRR_RI: sd00033 (415 - 439)

LRR_RI

LRR_RI: sd00033 (440 - 461)

LRR_RI

LRR_RI: sd00033 (462 - 484)

LRR_RI

LRR_RI: sd00033 (485 - 506)

LRR_RI

LRR_RI: sd00033 (507 - 530)

LRRCT

LRRCT: smart00082 (539 - 593)

TIR

TIR: smart00255 (651 - 794)

  • 0
  • 200
  • 400
  • 600
  • 808 a.a.
Protein Preferred Names Protein Names

toll-like receptor 1

  • rCG56938-like

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1180A Pam3CSK4 TFA Agonist 99.89% Unkown
HY-108471 CU-CPT22 Inhibitor ≥99.0% Unkown
HY-123942 Diprovocim Agonist 98.82% Unkown
HY-110353 CU-T12-9 Agonist 99.96% Unkown
HY-150501 Diprovocim-X Agonist 98.64% Unkown
HY-P1180 Pam3CSK4 Agonist / Unkown
HY-183301 TLR2/1 agonist-1 Agonist / Unkown
HY-P1405 Pam3CSK4-Biotin Agonist / Unkown
HY-175293 SMU-C68 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tlr1 NCBI NCBI:7096