2. Gene
  3. Rela - RELA proto-oncogene, NF-kB subunit Gene

Rela - RELA proto-oncogene, NF-kB subunit Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as NFkB; nos2

Gene ID: 309165 | Gene type: protein coding

About Rela

Primary_assembly 1: 202,924,945-202,935,484 forward strand.mRatBN7.2:CM026974.1

This gene has 5 transcripts (splice variants), 200 orthologues, 4 paralogues and is associated with 88 phenotypes. Biased expression in Lung (RPKM 143.3), Heart (RPKM 121.9) and 9 other tissues.

Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including positive regulation of cell differentiation; positive regulation of pri-miRNA transcription by RNA polymerase II; and response to cobalamin. Located in chromatin; cytosol; and nucleus. Part of protein-containing complex. Is active in synapse. Used to study Parkinsonism; encephalitis; fatty liver disease; and status epilepticus. Biomarker of several diseases, including acute necrotizing pancreatitis; artery disease (multiple); colitis; end stage renal disease; and uveitis. Human ortholog(s) of this gene implicated in ductal carcinoma in situ; lung non-small cell carcinoma; lymphoma; and renal cell carcinoma. Orthologous to human RELA (RELA proto-oncogene, NF-kB subunit). [provided by Alliance of Genome Resources, Apr 2022]

Rela Products(1)

mRNA Protein Name
NM_199267.2 NP_954888.1 transcription factor p65

Rela Protein Structure

RHD-n_RelA

RHD-n_RelA: cd07885 (18 - 186)

IPT_NFkappaB

IPT_NFkappaB: cd01177 (193 - 289)

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  • 550 a.a.
Protein Preferred Names Protein Names

transcription factor p65

nuclear factor kappa B subunit p65

nuclear factor kappaB subunit p65

v-rel avian reticuloendotheliosis viral oncogene homolog A

v-rel reticuloendotheliosis viral oncogene homolog A

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11826 RELA Human Pre-designed siRNA Set A / Unkown
HY-RS11827 Rela Mouse Pre-designed siRNA Set A / Unkown
HY-RS11828 Rela Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rela NCBI NCBI:5970
Canis familiaris Rela NCBI NCBI:483729
Macaca fascicularis Rela NCBI NCBI:101867324
Canis lupus familiaris Rela NCBI
Mus musculus Rela NCBI NCBI:19697
Macaca mulatta Rela NCBI NCBI:715919