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Rela - RELA proto-oncogene, NF-kB subunit Gene

Also Known as NFkB; nos2

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 309165

About Rela

Primary_assembly 1: 202,924,945-202,935,484 forward strand.mRatBN7.2:CM026974.1

This gene has 5 transcripts (splice variants), 200 orthologues, 4 paralogues and is associated with 88 phenotypes. Biased expression in Lung (RPKM 143.3), Heart (RPKM 121.9) and 9 other tissues.

Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including positive regulation of cell differentiation; positive regulation of pri-miRNA transcription by RNA polymerase II; and response to cobalamin. Located in chromatin; cytosol; and nucleus. Part of protein-containing complex. Is active in synapse. Used to study Parkinsonism; encephalitis; fatty liver disease; and status epilepticus. Biomarker of several diseases, including acute necrotizing pancreatitis; artery disease (multiple); colitis; end stage renal disease; and uveitis. Human ortholog(s) of this gene implicated in ductal carcinoma in situ; lung non-small cell carcinoma; lymphoma; and renal cell carcinoma. Orthologous to human RELA (RELA proto-oncogene, NF-kB subunit). [provided by Alliance of Genome Resources, Apr 2022]

Rela Products (1)

mRNA	Protein	Name
NM_199267.2	NP_954888.1	transcription factor p65

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	26908121	RGD
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	9585425	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15728586	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	12672265	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	9918814	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in acetaldehyde metabolic process	IEP IEP: Inferred from expression pattern	9918814	RGD
involved in cellular response to lipopolysaccharide	IDA IDA: Inferred from direct assay	15728586	RGD
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	9918814	RGD
involved in cellular response to tumor necrosis factor	IDA IDA: Inferred from direct assay	15980038	RGD
involved in negative regulation of insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18073321	RGD
involved in positive regulation of Schwann cell differentiation	IMP IMP: Inferred from mutant phenotype	18385332	RGD
involved in positive regulation of miRNA transcription	IMP IMP: Inferred from mutant phenotype	20546595	RGD
involved in response to amino acid	IEP IEP: Inferred from expression pattern	18288455	RGD
involved in response to cAMP	IEP IEP: Inferred from expression pattern	18385332	RGD
involved in response to cobalamin	IEP IEP: Inferred from expression pattern	18183619	RGD
involved in response to cytokine	IEP IEP: Inferred from expression pattern	10715573	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	29399060	RGD
involved in response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	17454138	RGD
involved in response to insulin	IEP IEP: Inferred from expression pattern	18500427	RGD
involved in response to ischemia	IEP IEP: Inferred from expression pattern	31583047	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	17915214	RGD
involved in response to mechanical stimulus	IEP IEP: Inferred from expression pattern	17525357	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	18400403	RGD
involved in response to progesterone	IEP IEP: Inferred from expression pattern	18274644	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	18543397	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	26908121	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	11912207	RGD
located in nucleus	IDA IDA: Inferred from direct assay	11912207	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	9343439	RGD
is active in synapse	EXP EXP: Inferred from Experiment	8297787	RGD
is active in synapse	IDA IDA: Inferred from direct assay	8297787	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Rela Protein Structure

RHD-n_RelA

IPT_NFkappaB

0
100
200
300
400
500
550 a.a.

Protein Preferred Names	Protein Names
transcription factor p65	nuclear factor kappa B subunit p65 nuclear factor kappaB subunit p65 v-rel avian reticuloendotheliosis viral oncogene homolog A v-rel reticuloendotheliosis viral oncogene homolog A

Rela Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Rela	Q7TQN4	Nos2	Rattus norvegicus	Q06518	Anti Bait CoIP	21464294

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-170316	Ibetazol	Inhibitor	99.80%	Unkown
HY-174864	JP-163-16		99.20%	Unkown
HY-N2441	Methylophiopogonone A	Inhibitor	99.84%	Unkown
HY-N7043	Isosilybin A		99.63%	Unkown
HY-RS11827	Rela Mouse Pre-designed siRNA Set A		/	Unkown
HY-121309	Doxorubicinone	Inhibitor	98.29%	Unkown
HY-RS11826	RELA Human Pre-designed siRNA Set A		/	Unkown
HY-101512D	rel-A-395 hydrochloride	Inhibitor	/	Unkown
HY-174865	MMH-165-26		/	Unkown
HY-RS11828	Rela Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rela	NCBI	NCBI:5970