MMH-165-26
MMH-165-26 is a ligand for RelA/p65. MMH-165-26 reduces the expression of RelA/p65 and has significant cytotoxicity in MEC-1 (LC50 = 0.37 μM) cells. MMH-165-26 can be used for synthesizing PROTACs such as JP-163-16 (HY-174864).
For research use only. We do not sell to patients.
- CAS No.: 3100147-71-2
- Formula: C23H26N4O4
- Molecular Weight:422.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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p65 |
MMH-165-26 (Compound 20d) (0.1-5 μM, 48 h) significantly inhibited the growth of MDA-MB-231 (LC50 = 6.7 μM) cells and degrades the level of RelA/p65 in a proteasome-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231 cells
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Concentration:0.1, 1, 5 μM
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Incubation Time:48 h
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Result:Significantly increased the apoptosis rate of cells.
Chemical Information
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CAS No. 3100147-71-2
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Molecular Weight 422.48
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Formula C23H26N4O4
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SMILES
NC1=CC=C(NC(CCCOC2=C(OC)C=C3C(N=C[C@@](CCC4)([H])N4C3=O)=C2)=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MMH-165-26 Related Classifications
HY-174865 Related Classifications
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