Elk1 - ETS transcription factor ELK1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 314436

Summary

This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-Fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. Multiple isoforms are produced from this gene by the use of alternative translational start codons. [provided by RefSeq, Mar 2012]

Elk1 Products (1)

mRNA Protein Name
NM_001108059.3 NP_001101529.1 ETS domain-containing protein Elk-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
11557580 RGD
enables chromatin binding IDA
IDA: Inferred from direct assay
18768922 RGD
enables double-stranded DNA binding IDA
IDA: Inferred from direct assay
11557580 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to gamma radiation IDA
IDA: Inferred from direct assay
17949253 RGD
involved in cellular response to lipid IDA
IDA: Inferred from direct assay
18768922 RGD
involved in cellular response to testosterone stimulus IEP
IEP: Inferred from expression pattern
14766003 RGD
involved in hippocampal neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
16549787 RGD
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19029245 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
18322102 RGD
involved in response to fibroblast growth factor IDA
IDA: Inferred from direct assay
17156131 RGD
involved in response to light stimulus IDA
IDA: Inferred from direct assay
10383826 RGD
Cellular Component GO Annotation Evidence References Source
located in axon terminus IDA
IDA: Inferred from direct assay
9412502 RGD
located in dendrite IDA
IDA: Inferred from direct assay
16549787 RGD
located in mitochondrial membrane IDA
IDA: Inferred from direct assay
16549787 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
16549787 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ETS domain-containing protein Elk-1

  • ELK1, ETS transcription factor

  • ELK1, member of ETS oncogene family

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-152860 Darizmetinib 99.94% Unkown
HY-135699 TD52 95.0% Unkown
HY-113592 ERK-IN-4 Inhibitor 98.30% Unkown
HY-135699A TD52 dihydrochloride 99.55% Unkown
HY-RS04305 ELK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-111000 BNC-1 / Unkown
HY-163323 AKR1C3-IN-12 / Unkown
HY-RS07131 KCNH8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-122241 MT477 Inhibitor / Unkown
HY-RS17329 Elk1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21611 Kcnh8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23784 Elk1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28129 Kcnh8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W585976 Benzo[a]pyrene diol epoxide / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Elk1 NCBI NCBI:2002