Epha4 - Eph receptor A4 Gene

Also Known as RGD1560587

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 316539

Summary

Enables Ephrin Receptor binding activity. Involved in several processes, including regulation of modification of synaptic structure; regulation of neuron projection development; and synapse pruning. Located in several cellular components, including dendrite; distal axon; and perikaryon. Is integral component of plasma membrane. Is active in glutamatergic synapse. Biomarker of toxic encephalopathy. Orthologous to human EphA4 (EPH receptor A4). [provided by Alliance of Genome Resources, Apr 2022]

Epha4 Products (1)

mRNA Protein Name
NM_001162411.1 NP_001155883.1 ephrin type-A receptor 4 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ephrin receptor binding IDA
IDA: Inferred from direct assay
10366629 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12775584 RGD
Biological Process GO Annotation Evidence References Source
involved in glial cell migration IMP
IMP: Inferred from mutant phenotype
20335460 RGD
NOT involved in negative regulation of axon regeneration IMP
IMP: Inferred from mutant phenotype
17418490 RGD
involved in negative regulation of axon regeneration IMP
IMP: Inferred from mutant phenotype
17970742 RGD
involved in positive regulation of dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
19414612 RGD
involved in regulation of modification of synaptic structure IGI
IGI: Inferred from genetic interaction
24658113 RGD
involved in regulation of synapse pruning EXP
EXP: Inferred from Experiment
17143272 RGD
involved in regulation of synapse pruning IDA
IDA: Inferred from direct assay
17143272 RGD
involved in regulation of synapse pruning IEP
IEP: Inferred from expression pattern
17143272 RGD
involved in regulation of synapse pruning IMP
IMP: Inferred from mutant phenotype
17143272 RGD
Cellular Component GO Annotation Evidence References Source
located in axon terminus IDA
IDA: Inferred from direct assay
19086003 RGD
located in axonal growth cone IDA
IDA: Inferred from direct assay
19086003 RGD
located in cell body IDA
IDA: Inferred from direct assay
19086003 RGD
located in cell projection IDA
IDA: Inferred from direct assay
19086003 RGD
located in cell surface IDA
IDA: Inferred from direct assay
19086003 RGD
located in cytoplasm IDA
IDA: Inferred from direct assay
12775584 RGD
located in dendrite IDA
IDA: Inferred from direct assay
19086003 RGD
located in dendritic shaft IDA
IDA: Inferred from direct assay
24658113 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
19086003 RGD
located in filopodium IDA
IDA: Inferred from direct assay
19086003 RGD
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
17143272 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
17143272 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
17143272 RGD
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
19086003 RGD
located in neuromuscular junction IDA
IDA: Inferred from direct assay
11414792 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
19086003 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
17143272 RGD
located in postsynaptic density IDA
IDA: Inferred from direct assay
17143272 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ephrin type-A receptor 4

Recombinant Epha4 Proteins

Cat. No. Product Name Accession Purity
HY-P75238 EphA4 Protein, Rat (HEK293, His) D3ZZK3 (V20-T547) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75239 EphA4 Protein, Rat (HEK293, Fc) D3ZZK3 (V20-T547) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0387 Rhynchophylline Inhibitor 99.75% Unkown
HY-P0177 123C4 Agonist 99.46% Unkown
HY-P2264 KYL peptide Inhibitor 99.65% Unkown
HY-P11035 APY-d3 Inhibitor 99.18% Unkown
HY-146375 UniPR505 Antagonist 99.68% Unkown
HY-P10579 123B9 Agonist 99.67% Unkown
HY-W078239 EPHA4 antagonist-1 Antagonist 95.61% Unkown
HY-10654 EphB4-IN-2 Inhibitor / Unkown
HY-159174 EPHA2/A4/GAK-IN-1 Inhibitor / Unkown
HY-P11015 (123B9)2-Motif Agonist / Unkown
HY-P11243 EphA4 agonist compound 23 Agonist / Unkown
HY-P11244 150D4 Agonist / Unkown
HY-RS04428 EPHA4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17700 Epha4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24162 Epha4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991974 Anti-EPHA4 Antibody Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Epha4 NCBI NCBI:2043