Lig4 - ligase IV, DNA, ATP-dependent Gene

Also Known as tiny; 5830471N16Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 319583

Summary

Enables ATP binding activity and DNA Ligase (ATP) activity. Involved in double-strand break repair via nonhomologous end joining. Acts upstream of or within several processes, including DNA metabolic process; hemopoiesis; and nervous system development. Part of DNA-dependent protein kinase-DNA Ligase 4 complex. Is expressed in metanephros. Used to study DNA Ligase IV deficiency. Human ortholog(s) of this gene implicated in several diseases, including DNA Ligase IV deficiency; colorectal cancer; high grade glioma; multiple myeloma; and prostate Cancer. Orthologous to human LIG4 (DNA Ligase 4). [provided by Alliance of Genome Resources, Apr 2022]

Lig4 Products (2)

mRNA Protein Name
NM_001377042.1 NP_001363971.1 DNA ligase 4
NM_176953.4 NP_795927.2 DNA ligase 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
15194694 MGI
enables DNA ligase (ATP) activity IDA
IDA: Inferred from direct assay
15194694 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
20620605 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within DN2 thymocyte differentiation IMP
IMP: Inferred from mutant phenotype
9823897 MGI
acts upstream of or within DNA ligation IDA
IDA: Inferred from direct assay
15194694 MGI
acts upstream of or within DNA ligation IMP
IMP: Inferred from mutant phenotype
15968270 MGI
acts upstream of or within DNA ligation involved in DNA recombination IMP
IMP: Inferred from mutant phenotype
9823897 MGI
acts upstream of or within DNA ligation involved in DNA repair IMP
IMP: Inferred from mutant phenotype
9823897 MGI
acts upstream of or within DNA repair IMP
IMP: Inferred from mutant phenotype
11779495 MGI
acts upstream of or within T cell receptor V(D)J recombination IMP
IMP: Inferred from mutant phenotype
10911993 MGI
acts upstream of or within V(D)J recombination IDA
IDA: Inferred from direct assay
15194694 MGI
acts upstream of or within V(D)J recombination IMP
IMP: Inferred from mutant phenotype
10716994 MGI
acts upstream of or within central nervous system development IGI
IGI: Inferred from genetic interaction
10911993 MGI
acts upstream of or within central nervous system development IMP
IMP: Inferred from mutant phenotype
9875844 MGI
acts upstream of or within chromosome organization IGI
IGI: Inferred from genetic interaction
15175260 MGI
acts upstream of or within double-strand break repair IGI
IGI: Inferred from genetic interaction
12531011 MGI
acts upstream of or within double-strand break repair IMP
IMP: Inferred from mutant phenotype
12531011 MGI
acts upstream of or within double-strand break repair via nonhomologous end joining IMP
IMP: Inferred from mutant phenotype
10823907 MGI
involved in double-strand break repair via nonhomologous end joining IMP
IMP: Inferred from mutant phenotype
12361565 MGI
acts upstream of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
9823897 MGI
acts upstream of or within fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
15175260 MGI
acts upstream of or within immunoglobulin V(D)J recombination IMP
IMP: Inferred from mutant phenotype
9823897 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
9823897 MGI
acts upstream of or within isotype switching IMP
IMP: Inferred from mutant phenotype
17713479 MGI
acts upstream of or within negative regulation of neuron apoptotic process IGI
IGI: Inferred from genetic interaction
10911993 MGI
acts upstream of or within negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
9875844 MGI
acts upstream of neurogenesis IMP
IMP: Inferred from mutant phenotype
9875844 MGI
acts upstream of neuron apoptotic process IGI
IGI: Inferred from genetic interaction
10911993 MGI
acts upstream of or within neuron apoptotic process IGI
IGI: Inferred from genetic interaction
11248063 MGI
acts upstream of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
9875844 MGI
acts upstream of or within positive regulation of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
9823897 MGI
acts upstream of or within positive regulation of neurogenesis IMP
IMP: Inferred from mutant phenotype
9875844 MGI
acts upstream of or within pro-B cell differentiation IMP
IMP: Inferred from mutant phenotype
9823897 MGI
acts upstream of or within response to gamma radiation IMP
IMP: Inferred from mutant phenotype
9823897 MGI
acts upstream of or within response to ionizing radiation IMP
IMP: Inferred from mutant phenotype
10823907 MGI
acts upstream of or within somatic stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
17554302 MGI
acts upstream of or within stem cell proliferation IMP
IMP: Inferred from mutant phenotype
17554302 MGI
Cellular Component GO Annotation Evidence References Source
part of DNA-dependent protein kinase-DNA ligase 4 complex IDA
IDA: Inferred from direct assay
15194694 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA ligase 4

  • DNA ligase IV

  • polydeoxyribonucleotide synthase [ATP] 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07644 LIG4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19909 Lig4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26410 Lig4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lig4 NCBI NCBI:3981